Phylogenetic perspectives in innate immunity.

by: JA Hoffmann, FC Kafatos, CA Janeway, RA Ezekowitz

Science, Vol. 284, No. 5418. (21 May 1999), pp. 1313-1318.

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Abstract

The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.

@article{citeulike:463878, abstract = {The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity.}, address = {Institute of Molecular and Cellular Biology, CNRS, Strasbourg, 67084, France. jhoff@ibmc.u-strasbg.fr}, author = {Hoffmann, J. A. and Kafatos, F. C. and Janeway, C. A. and Ezekowitz, R. A. }, citeulike-article-id = {463878}, doi = {http://dx.doi.org/10.1126/science.284.5418.1313}, issn = {0036-8075}, journal = {Science}, keywords = {evolution, immune, innate}, month = {May}, number = {5418}, pages = {1313--1318}, posted-at = {2008-07-08 19:42:51}, priority = {2}, title = {Phylogenetic perspectives in innate immunity.}, url = {http://dx.doi.org/10.1126/science.284.5418.1313}, volume = {284}, year = {1999} }

RIS record

TY - JOUR ID - citeulike:463878 L3 - citeulike-article-id:463878 TI - Phylogenetic perspectives in innate immunity. JF - Science VL - 284 IS - 5418 SP - 1313 EP - 1318 AD - Institute of Molecular and Cellular Biology, CNRS, Strasbourg, 67084, France. jhoff@ibmc.u-strasbg.fr SN - 0036-8075 N2 - The concept of innate immunity refers to the first-line host defense that serves to limit infection in the early hours after exposure to microorganisms. Recent data have highlighted similarities between pathogen recognition, signaling pathways, and effector mechanisms of innate immunity in Drosophila and mammals, pointing to a common ancestry of these defenses. In addition to its role in the early phase of defense, innate immunity in mammals appears to play a key role in stimulating the subsequent, clonal response of adaptive immunity. KW - evolution KW - immune KW - innate AU - Hoffmann, JA AU - Kafatos, FC AU - Janeway, CA AU - Ezekowitz, RA PY - 1999/05/21/ UR - http://dx.doi.org/10.1126/science.284.5418.1313 ER -

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