Primordial emergence of the recombination activating gene 1 (RAG1): sequence of the complete shark gene indicates homology to microbial integrases Export

@article{citeulike:6060181, abstract = {The rearrangement of antibody and T-cell receptor gene segments is indispensable to the vertebrate immune response. All extant jawed vertebrates can rearrange these gene segments. This ability is conferred by the recombination activating genes I and II (RAG I and RAG II). To elucidate their origin and function, the cDNA encoding RAG I from a member of the most ancient class of extant gnathostomes, the Carcharhine sharks, was characterized. Homology domains identified within shark RAG I prompted sequence comparison analyses that suggested similarity of the RAG I and II genes, respectively, to the integrase family genes and integration host factor genes of the bacterial site-specific recombination system. Thus, the apparent explosive evolution (or "big bang") of the ancestral immune system may have been initiated by a transfer of microbial site-specific recombinases.}, author = {Bernstein, R. M. and Schluter, S. F. and Bernstein, H. and Marchalonis, J. J.}, citeulike-article-id = {6060181}, citeulike-linkout-0 = {http://www.pnas.org/content/93/18/9454.abstract}, citeulike-linkout-1 = {http://www.pnas.org/content/93/18/9454.full.pdf}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/8790351}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=8790351}, day = {3}, journal = {Proceedings of the National Academy of Sciences of the United States of America}, keywords = {adaptive\_immune\_system, big\_bang, evolution, gnathostomes, homology, origin, rag}, month = {September}, number = {18}, pages = {9454--9459}, posted-at = {2009-11-03 12:43:14}, priority = {2}, title = {Primordial emergence of the recombination activating gene 1 (RAG1): sequence of the complete shark gene indicates homology to microbial integrases}, url = {http://www.pnas.org/content/93/18/9454.abstract}, volume = {93}, year = {1996} }

TY - JOUR ID - citeulike:6060181 L3 - citeulike-article-id:6060181 N2 - The rearrangement of antibody and T-cell receptor gene segments is indispensable to the vertebrate immune response. All extant jawed vertebrates can rearrange these gene segments. This ability is conferred by the recombination activating genes I and II (RAG I and RAG II). To elucidate their origin and function, the cDNA encoding RAG I from a member of the most ancient class of extant gnathostomes, the Carcharhine sharks, was characterized. Homology domains identified within shark RAG I prompted sequence comparison analyses that suggested similarity of the RAG I and II genes, respectively, to the integrase family genes and integration host factor genes of the bacterial site-specific recombination system. Thus, the apparent explosive evolution (or "big bang") of the ancestral immune system may have been initiated by a transfer of microbial site-specific recombinases. IS - 18 JF - Proceedings of the National Academy of Sciences of the United States of America EP - 9459 TI - Primordial emergence of the recombination activating gene 1 (RAG1): sequence of the complete shark gene indicates homology to microbial integrases VL - 93 SP - 9454 KW - adaptive_immune_system KW - big_bang KW - evolution KW - gnathostomes KW - homology KW - origin KW - rag AU - Bernstein, RM AU - Schluter, SF AU - Bernstein, H AU - Marchalonis, JJ PY - 1996/09/03/ UR - http://www.pnas.org/content/93/18/9454.abstract ER -