DNA Transposition by the RAG1 and RAG2 ProteinsA Possible Source of Oncogenic Translocations Export

@article{citeulike:6061219, abstract = {The RAG1 and RAG2 proteins are known to initiate V(D)J recombination by making a double-strand break between the recombination signal sequence (RSS) and the neighboring coding DNA. We show that these proteins can also drive the coupled insertion of cleaved recombination signals into new DNA sites in a transpositional reaction. This RAG-mediated DNA transfer provides strong evidence for the evolution of the V(D)J recombination system from an ancient mobile DNA element and suggests that repeated transposition may have promoted the expansion of the antigen receptor loci. The inappropriate diversion of V(D)J rearrangement to a transpositional pathway may also help to explain certain types of DNA translocation associated with lymphatic tumors.}, author = {Hiom, K.}, citeulike-article-id = {6061219}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/S0092-8674(00)81587-1}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0092-8674(00)81587-1}, doi = {10.1016/S0092-8674(00)81587-1}, issn = {00928674}, journal = {Cell}, keywords = {evolution, immune, origin, rag, transposon}, month = {August}, number = {4}, pages = {463--470}, posted-at = {2009-11-03 17:44:39}, priority = {2}, title = {DNA Transposition by the RAG1 and RAG2 ProteinsA Possible Source of Oncogenic Translocations}, url = {http://dx.doi.org/10.1016/S0092-8674(00)81587-1}, volume = {94}, year = {1998} }

TY - JOUR ID - citeulike:6061219 L3 - citeulike-article-id:6061219 N2 - The RAG1 and RAG2 proteins are known to initiate V(D)J recombination by making a double-strand break between the recombination signal sequence (RSS) and the neighboring coding DNA. We show that these proteins can also drive the coupled insertion of cleaved recombination signals into new DNA sites in a transpositional reaction. This RAG-mediated DNA transfer provides strong evidence for the evolution of the V(D)J recombination system from an ancient mobile DNA element and suggests that repeated transposition may have promoted the expansion of the antigen receptor loci. The inappropriate diversion of V(D)J rearrangement to a transpositional pathway may also help to explain certain types of DNA translocation associated with lymphatic tumors. IS - 4 JF - Cell SN - 00928674 EP - 470 TI - DNA Transposition by the RAG1 and RAG2 ProteinsA Possible Source of Oncogenic Translocations VL - 94 SP - 463 KW - evolution KW - immune KW - origin KW - rag KW - transposon AU - Hiom, K PY - 1998/08// UR - http://dx.doi.org/10.1016/S0092-8674(00)81587-1 ER -