Does the APC/C Mark MIWI and piRNAs for a Final Farewell?
Recently in Developmental Cell, Zhao et al. (2013) reported a mechanism for the directed turnover of the mouse Piwi protein MIWI during sperm maturation. This study implicates the anaphase-promoting complex as a mediator of MIWI ubiquitination and expands the avenues for regulating small RNA processes. Copyright © 2013 Elsevier Inc. All rights reserved.