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Nature, Vol. 460, No. 7251. (2 July 2009), pp. 49-52, doi:10.1038/nature08180 Key: citeulike:5035475
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Induced pluripotent stem cells offer unprecedented potential for disease research, drug screening, toxicology and regenerative medicine. However, the process of reprogramming is inefficient and often incomplete. Here I consider reasons for bottlenecks in induced pluripotent stem cell generation, and propose a model in which most or all cells have the potential to become pluripotent.
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