RNA polymerase active center: the molecular engine of transcription. Export

@article{citeulike:5042791, abstract = {RNA polymerase (RNAP) is a complex molecular machine that governs gene expression and its regulation in all cellular organisms. To accomplish its function of accurately producing a full-length RNA copy of a gene, RNAP performs a plethora of chemical reactions and undergoes multiple conformational changes in response to cellular conditions. At the heart of this machine is the active center, the engine, which is composed of distinct fixed and moving parts that serve as the ultimate acceptor of regulatory signals and as the target of inhibitory drugs. Recent advances in the structural and biochemical characterization of RNAP explain the active center at the atomic level and enable new approaches to understanding the entire transcription mechanism, its exceptional fidelity and control.}, author = {Nudler, E.}, citeulike-article-id = {5042791}, citeulike-linkout-0 = {http://dx.doi.org/10.1146/annurev.biochem.76.052705.164655}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/19489723}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=19489723}, doi = {10.1146/annurev.biochem.76.052705.164655}, issn = {1545-4509}, journal = {Annual review of biochemistry}, keywords = {pol, review, rna}, pages = {335--361}, posted-at = {2009-07-02 15:00:11}, priority = {2}, title = {RNA polymerase active center: the molecular engine of transcription.}, url = {http://dx.doi.org/10.1146/annurev.biochem.76.052705.164655}, volume = {78}, year = {2009} }

TY - JOUR ID - citeulike:5042791 L3 - citeulike-article-id:5042791 N2 - RNA polymerase (RNAP) is a complex molecular machine that governs gene expression and its regulation in all cellular organisms. To accomplish its function of accurately producing a full-length RNA copy of a gene, RNAP performs a plethora of chemical reactions and undergoes multiple conformational changes in response to cellular conditions. At the heart of this machine is the active center, the engine, which is composed of distinct fixed and moving parts that serve as the ultimate acceptor of regulatory signals and as the target of inhibitory drugs. Recent advances in the structural and biochemical characterization of RNAP explain the active center at the atomic level and enable new approaches to understanding the entire transcription mechanism, its exceptional fidelity and control. JF - Annual review of biochemistry SN - 1545-4509 EP - 361 TI - RNA polymerase active center: the molecular engine of transcription. VL - 78 SP - 335 KW - pol KW - review KW - rna AU - Nudler, E PY - 2009/// UR - http://dx.doi.org/10.1146/annurev.biochem.76.052705.164655 ER -