From the Cover: Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation Export

@article{citeulike:2095851, abstract = {There is controversy over the nature of the disturbance in brain development that underpins attention-deficit/hyperactivity disorder (ADHD). In particular, it is unclear whether the disorder results from a delay in brain maturation or whether it represents a complete deviation from the template of typical development. Using computational neuroanatomic techniques, we estimated cortical thickness at >40,000 cerebral points from 824 magnetic resonance scans acquired prospectively on 223 children with ADHD and 223 typically developing controls. With this sample size, we could define the growth trajectory of each cortical point, delineating a phase of childhood increase followed by adolescent decrease in cortical thickness (a quadratic growth model). From these trajectories, the age of attaining peak cortical thickness was derived and used as an index of cortical maturation. We found maturation to progress in a similar manner regionally in both children with and without ADHD, with primary sensory areas attaining peak cortical thickness before polymodal, high-order association areas. However, there was a marked delay in ADHD in attaining peak thickness throughout most of the cerebrum: the median age by which 50\% of the cortical points attained peak thickness for this group was 10.5 years (SE 0.01), which was significantly later than the median age of 7.5 years (SE 0.02) for typically developing controls (log rank test {chi}(1)2 = 5,609, P < 1.0 x 1020). The delay was most prominent in prefrontal regions important for control of cognitive processes including attention and motor planning. Neuroanatomic documentation of a delay in regional cortical maturation in ADHD has not been previously reported. 10.1073/pnas.0707741104}, author = {Shaw, P. and Eckstrand, K. and Sharp, W. and Blumenthal, J. and Lerch, J. P. and Greenstein, D. and Clasen, L. and Evans, A. and Giedd, J. and Rapoport, J. L.}, citeulike-article-id = {2095851}, citeulike-linkout-0 = {http://dx.doi.org/10.1073/pnas.0707741104}, citeulike-linkout-1 = {http://www.pnas.org/cgi/content/abstract/104/49/19649}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18024590}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18024590}, day = {4}, doi = {10.1073/pnas.0707741104}, journal = {Proceedings of the National Academy of Sciences}, keywords = {adhd, delayed, maturation, neuroanatomic}, month = {December}, number = {49}, pages = {19649--19654}, posted-at = {2007-12-11 22:22:57}, priority = {2}, title = {From the Cover: Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation}, url = {http://dx.doi.org/10.1073/pnas.0707741104}, volume = {104}, year = {2007} }

TY - JOUR ID - citeulike:2095851 L3 - citeulike-article-id:2095851 N2 - There is controversy over the nature of the disturbance in brain development that underpins attention-deficit/hyperactivity disorder (ADHD). In particular, it is unclear whether the disorder results from a delay in brain maturation or whether it represents a complete deviation from the template of typical development. Using computational neuroanatomic techniques, we estimated cortical thickness at >40,000 cerebral points from 824 magnetic resonance scans acquired prospectively on 223 children with ADHD and 223 typically developing controls. With this sample size, we could define the growth trajectory of each cortical point, delineating a phase of childhood increase followed by adolescent decrease in cortical thickness (a quadratic growth model). From these trajectories, the age of attaining peak cortical thickness was derived and used as an index of cortical maturation. We found maturation to progress in a similar manner regionally in both children with and without ADHD, with primary sensory areas attaining peak cortical thickness before polymodal, high-order association areas. However, there was a marked delay in ADHD in attaining peak thickness throughout most of the cerebrum: the median age by which 50% of the cortical points attained peak thickness for this group was 10.5 years (SE 0.01), which was significantly later than the median age of 7.5 years (SE 0.02) for typically developing controls (log rank test {chi}(1)2 = 5,609, P < 1.0 x 1020). The delay was most prominent in prefrontal regions important for control of cognitive processes including attention and motor planning. Neuroanatomic documentation of a delay in regional cortical maturation in ADHD has not been previously reported. 10.1073/pnas.0707741104 IS - 49 JF - Proceedings of the National Academy of Sciences EP - 19654 TI - From the Cover: Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation VL - 104 SP - 19649 KW - adhd KW - delayed KW - maturation KW - neuroanatomic AU - Shaw, P AU - Eckstrand, K AU - Sharp, W AU - Blumenthal, J AU - Lerch, JP AU - Greenstein, D AU - Clasen, L AU - Evans, A AU - Giedd, J AU - Rapoport, JL PY - 2007/12/04/ UR - http://dx.doi.org/10.1073/pnas.0707741104 ER -