Noninvasive ventilation in hypercapnic acute respiratory failure due to chronic obstructive pulmonary disease vs. other conditions: effectiveness and predictors of failure. Export

@article{citeulike:5270541, abstract = {OBJECTIVE: This study compared the effectiveness of noninvasive ventilation (NIV) and the risk factors for NIV failure in hypercapnic acute respiratory failure (ARF) due to chronic obstructive pulmonary disease (COPD) vs. non-COPD conditions. DESIGN AND SETTING: Prospective cohort study in the medical intensive care unit of a university hospital. PATIENTS AND PARTICIPANTS: 111 patients with hypercapnic ARF, 43 of whom had COPD exacerbations and 68 other conditions. Baseline characteristics of the two groups were similar. MEASUREMENTS AND RESULTS: The risk of NIV failure, defined as the need for endotracheal intubation, was significantly lower in COPD than in other conditions (19\% vs. 47\%). High APACHE II score was an independent predictor of NIV failure in COPD (OR 5.38 per 5 points). The presence of pneumonia (OR 5.63), high APACHE II score (OR 2.59 per 5 points), rapid heart rate (OR 1.22 per 5 beats/min), and high PaCO(2) 1 h after NIV (OR 1.22 per 5 mmHg) were independent predictors of NIV failure in the non-COPD group. Failure of NIV independently predicted mortality (OR 10.53). CONCLUSIONS: Noninvasive ventilation was more effective in preventing endotracheal intubation in hypercapnic ARF due to COPD than non-COPD conditions. High APACHE II score predicted NIV failure in both groups. Noninvasive ventilation was least effective in patients with hypercapnic ARF due to pneumonia.}, author = {Phua, J. and Kong, K. and Lee, K. H. and Shen, L. and Lim, T. K.}, citeulike-article-id = {5270541}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00134-005-2582-8}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/15742175}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=15742175}, doi = {10.1007/s00134-005-2582-8}, issn = {0342-4642}, journal = {Intensive care medicine}, keywords = {aecopd, apo, arf, cohort, copd, icu, niv, nivfailure, t2rf}, month = {April}, number = {4}, pages = {533--539}, posted-at = {2009-07-26 12:17:26}, priority = {2}, title = {Noninvasive ventilation in hypercapnic acute respiratory failure due to chronic obstructive pulmonary disease vs. other conditions: effectiveness and predictors of failure.}, url = {http://dx.doi.org/10.1007/s00134-005-2582-8}, volume = {31}, year = {2005} }

TY - JOUR ID - citeulike:5270541 L3 - citeulike-article-id:5270541 N2 - OBJECTIVE: This study compared the effectiveness of noninvasive ventilation (NIV) and the risk factors for NIV failure in hypercapnic acute respiratory failure (ARF) due to chronic obstructive pulmonary disease (COPD) vs. non-COPD conditions. DESIGN AND SETTING: Prospective cohort study in the medical intensive care unit of a university hospital. PATIENTS AND PARTICIPANTS: 111 patients with hypercapnic ARF, 43 of whom had COPD exacerbations and 68 other conditions. Baseline characteristics of the two groups were similar. MEASUREMENTS AND RESULTS: The risk of NIV failure, defined as the need for endotracheal intubation, was significantly lower in COPD than in other conditions (19% vs. 47%). High APACHE II score was an independent predictor of NIV failure in COPD (OR 5.38 per 5 points). The presence of pneumonia (OR 5.63), high APACHE II score (OR 2.59 per 5 points), rapid heart rate (OR 1.22 per 5 beats/min), and high PaCO(2) 1 h after NIV (OR 1.22 per 5 mmHg) were independent predictors of NIV failure in the non-COPD group. Failure of NIV independently predicted mortality (OR 10.53). CONCLUSIONS: Noninvasive ventilation was more effective in preventing endotracheal intubation in hypercapnic ARF due to COPD than non-COPD conditions. High APACHE II score predicted NIV failure in both groups. Noninvasive ventilation was least effective in patients with hypercapnic ARF due to pneumonia. IS - 4 JF - Intensive care medicine SN - 0342-4642 EP - 539 TI - Noninvasive ventilation in hypercapnic acute respiratory failure due to chronic obstructive pulmonary disease vs. other conditions: effectiveness and predictors of failure. VL - 31 SP - 533 KW - aecopd KW - apo KW - arf KW - cohort KW - copd KW - icu KW - niv KW - nivfailure KW - t2rf AU - Phua, J AU - Kong, K AU - Lee, KH AU - Shen, L AU - Lim, TK PY - 2005/04// UR - http://dx.doi.org/10.1007/s00134-005-2582-8 ER -