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Evolution of prokaryotic gene order: genome rearrangements in closely related species. Export

by: M. Suyama, P. Bork
Trends Genet, Vol. 17, No. 1. (January 2001), pp. 10-13.

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closely-related evolution gene-order genome-evolution genome-rearrangement prokaryote species

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Conservation of gene order in prokaryotes has become important in predicting protein function because, over the evolutionary timescale, genomes are shuffled so that local gene-order conservation reflects the functional constraints within the protein. Here, we compare closely related genomes to identify the rate with which gene order is disrupted and to infer the genes involved in the genome rearrangement.


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