Estimating the size of the bacterial pan-genome. Export

@article{citeulike:4075778, abstract = {The 'pan-genome' denotes the set of all genes present in the genomes of a group of organisms. Here, we extend the pan-genome concept to higher taxonomic units. Using 573 sequenced genomes, we estimate the size of the bacterial pan-genome based on the frequency of occurrences of genes among sampled genomes. Using gene- and genome-centered approaches, we characterize three distinct pools of gene families that comprise the bacterial pan-genome, each evolving under different evolutionary constraints. Our findings indicate that the pan-genome of the bacterial domain is of infinite size (the Bacteria as a whole have an open pan-genome) and that approximately 250 genes per genome belong to the extended bacterial core genome.}, author = {Lapierre, Pascal and Gogarten, J. Peter}, citeulike-article-id = {4075778}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.tig.2008.12.004}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0168952509000055}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19168257}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19168257}, day = {23}, doi = {10.1016/j.tig.2008.12.004}, issn = {0168-9525}, journal = {Trends in genetics : TIG}, month = {March}, number = {3}, pages = {107--110}, posted-at = {2009-10-30 12:05:35}, priority = {2}, title = {Estimating the size of the bacterial pan-genome.}, url = {http://dx.doi.org/10.1016/j.tig.2008.12.004}, volume = {25}, year = {2009} }

TY - JOUR ID - citeulike:4075778 L3 - citeulike-article-id:4075778 N2 - The 'pan-genome' denotes the set of all genes present in the genomes of a group of organisms. Here, we extend the pan-genome concept to higher taxonomic units. Using 573 sequenced genomes, we estimate the size of the bacterial pan-genome based on the frequency of occurrences of genes among sampled genomes. Using gene- and genome-centered approaches, we characterize three distinct pools of gene families that comprise the bacterial pan-genome, each evolving under different evolutionary constraints. Our findings indicate that the pan-genome of the bacterial domain is of infinite size (the Bacteria as a whole have an open pan-genome) and that approximately 250 genes per genome belong to the extended bacterial core genome. IS - 3 JF - Trends in genetics : TIG SN - 0168-9525 EP - 110 TI - Estimating the size of the bacterial pan-genome. VL - 25 SP - 107 AU - Lapierre, Pascal AU - Gogarten, Peter PY - 2009/03/23/ UR - http://dx.doi.org/10.1016/j.tig.2008.12.004 ER -