Caveolae and caveolin-1: novel potential targets for the treatment of cardiovascular disease. Export

@article{citeulike:1410220, abstract = {Caveolae are 50-100 nm cell surface plasma membrane invaginations that are highly enriched in cholesterol and sphingolipids and are characterized by the protein marker caveolin-1. Caveolin-1 is highly expressed in terminally differentiated cells. Among these cells, endothelial cells, smooth muscle cells, and macrophages have all been shown to play key roles in the development of vascular disease. Atherosclerosis and neointimal formation are two major processes that have been associated with arterial occlusion. In both cases, caveolin-1 has been shown to play an important role. However, depending on the cell type and the metabolic pathways regulated by this protein, caveolin-1 may positively or negatively influence the development of vascular disease. Both of these aspects will be discussed in this review.}, address = {Kimmel Cancer Center, Departments of Cancer Biology, and Biochemistry and Molecular Biology, Thomas Jefferson University, 233 South 10th Street, BLSB (Bluemle Life Sciences Building), Room 933, Philadelphia, PA 19107, USA; philippe.frank@jefferson.edu.}, author = {Frank, P. G. and Hassan, G. S. and Rodriguez-Feo, J. A. and Lisanti, M. P.}, citeulike-article-id = {1410220}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/17584106}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=17584106}, issn = {1873-4286}, journal = {Curr Pharm Des}, keywords = {caveolin-1, clinical, review}, number = {17}, pages = {1761--1769}, posted-at = {2007-06-25 08:58:19}, priority = {3}, title = {Caveolae and caveolin-1: novel potential targets for the treatment of cardiovascular disease.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/17584106}, volume = {13}, year = {2007} }

TY - JOUR ID - citeulike:1410220 L3 - citeulike-article-id:1410220 N2 - Caveolae are 50-100 nm cell surface plasma membrane invaginations that are highly enriched in cholesterol and sphingolipids and are characterized by the protein marker caveolin-1. Caveolin-1 is highly expressed in terminally differentiated cells. Among these cells, endothelial cells, smooth muscle cells, and macrophages have all been shown to play key roles in the development of vascular disease. Atherosclerosis and neointimal formation are two major processes that have been associated with arterial occlusion. In both cases, caveolin-1 has been shown to play an important role. However, depending on the cell type and the metabolic pathways regulated by this protein, caveolin-1 may positively or negatively influence the development of vascular disease. Both of these aspects will be discussed in this review. IS - 17 JF - Curr Pharm Des SN - 1873-4286 AD - Kimmel Cancer Center, Departments of Cancer Biology, and Biochemistry and Molecular Biology, Thomas Jefferson University, 233 South 10th Street, BLSB (Bluemle Life Sciences Building), Room 933, Philadelphia, PA 19107, USA; philippe.frank@jefferson.edu. EP - 1769 TI - Caveolae and caveolin-1: novel potential targets for the treatment of cardiovascular disease. VL - 13 SP - 1761 KW - caveolin-1 KW - clinical KW - review AU - Frank, PG AU - Hassan, GS AU - Rodriguez-Feo, JA AU - Lisanti, MP PY - 2007/// UR - http://view.ncbi.nlm.nih.gov/pubmed/17584106 ER -