Lipid rafts in membrane-cytoskeleton interactions and control of cellular biomechanics: actions of oxLDL. Export

@article{citeulike:1738913, abstract = {Membrane-cytoskeleton coupling is known to play major roles in a plethora of cellular responses, such as cell growth, differentiation, polarization, motility, and others. In this review, the authors discuss the growing amount of evidence indicating that membrane-cytoskeleton interactions are regulated by the lipid composition of the plasma membrane, suggesting that cholesterol-rich membrane domains (lipid rafts), including caveolae, are essential for membrane-cytoskeleton coupling. Several models for raft-cytoskeleton interactions are discussed. Also described is the evidence suggesting that raft-cytoskeleton interactions play key roles in several cytoskeleton-dependent processes, particularly in the regulation of cellular biomechanical properties. To address further the physiological significance of raft-cytoskeleton coupling, the authors focus on the impact of oxidized low density lipoproteins, one of the major cholesterol carriers and proatherogenic factors, on the integrity of lipid rafts/caveolae, and on the organization of the cytoskeleton. Finally, the authors review the recent studies showing that oxLDL and cholesterol depletion have similar impacts on the biomechanical properties of vascular endothelial cells, which in turn affect endothelial angiogenic potential.}, address = {Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA. levitan@uic.edu}, author = {Levitan, I. and Gooch, K. J.}, citeulike-article-id = {1738913}, citeulike-linkout-0 = {http://dx.doi.org/10.1089/ars.2007.1686}, citeulike-linkout-1 = {http://www.liebertonline.com/doi/abs/10.1089/ars.2007.1686}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17576163}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17576163}, doi = {10.1089/ars.2007.1686}, issn = {1523-0864}, journal = {Antioxid Redox Signal}, keywords = {caveolae, cholesterol, cytoskeleton, membrane, oxldl, raft, rafts, review}, month = {September}, number = {9}, pages = {1519--1534}, posted-at = {2007-10-08 07:20:47}, priority = {4}, title = {Lipid rafts in membrane-cytoskeleton interactions and control of cellular biomechanics: actions of oxLDL.}, url = {http://dx.doi.org/10.1089/ars.2007.1686}, volume = {9}, year = {2007} }

TY - JOUR ID - citeulike:1738913 L3 - citeulike-article-id:1738913 N2 - Membrane-cytoskeleton coupling is known to play major roles in a plethora of cellular responses, such as cell growth, differentiation, polarization, motility, and others. In this review, the authors discuss the growing amount of evidence indicating that membrane-cytoskeleton interactions are regulated by the lipid composition of the plasma membrane, suggesting that cholesterol-rich membrane domains (lipid rafts), including caveolae, are essential for membrane-cytoskeleton coupling. Several models for raft-cytoskeleton interactions are discussed. Also described is the evidence suggesting that raft-cytoskeleton interactions play key roles in several cytoskeleton-dependent processes, particularly in the regulation of cellular biomechanical properties. To address further the physiological significance of raft-cytoskeleton coupling, the authors focus on the impact of oxidized low density lipoproteins, one of the major cholesterol carriers and proatherogenic factors, on the integrity of lipid rafts/caveolae, and on the organization of the cytoskeleton. Finally, the authors review the recent studies showing that oxLDL and cholesterol depletion have similar impacts on the biomechanical properties of vascular endothelial cells, which in turn affect endothelial angiogenic potential. IS - 9 JF - Antioxid Redox Signal SN - 1523-0864 AD - Department of Medicine, University of Illinois at Chicago, Chicago, Illinois 60612, USA. levitan@uic.edu EP - 1534 TI - Lipid rafts in membrane-cytoskeleton interactions and control of cellular biomechanics: actions of oxLDL. VL - 9 SP - 1519 KW - caveolae KW - cholesterol KW - cytoskeleton KW - membrane KW - oxldl KW - raft KW - rafts KW - review AU - Levitan, I AU - Gooch, KJ PY - 2007/09// UR - http://dx.doi.org/10.1089/ars.2007.1686 ER -