Caveolae and transcytosis in endothelial cells: role in atherosclerosis. Export

@article{citeulike:3154865, abstract = {The endothelium plays an important role in the regulation of molecular exchanges between the blood and peripheral tissues. The transport of molecules between tissues must be tightly controlled in order to maintain homeostasis between the different organs of the body. The endothelial transcytosis pathway has been shown to direct the transfer of proteins and solutes and therefore to act as a filtering system. This transport mode has been demonstrated to involve plasma-membrane vesicles that may be transferred with their cargo components from the apical to the basal side of endothelial cells. Among the vesicles implicated in the regulation of transcytosis, caveolae, which are 50 to 100-nm plasma-membrane invaginations, have been reported to play an essential part. In this paper, we review the function of caveolae and their major protein component (i.e., caveolin-1) in the regulation of endothelial transcytosis. The roles of caveolae in vascular diseases, such as atherosclerosis, are discussed.}, address = {Kimmel Cancer Center, Departments of Cancer Biology, and Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA, philippe.frank@jefferson.edu.}, author = {Frank, Philippe G. and Pavlides, Stephanos and Lisanti, Michael P.}, citeulike-article-id = {3154865}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s00441-008-0659-8}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18688651}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18688651}, doi = {10.1007/s00441-008-0659-8}, issn = {0302-766X}, journal = {Cell and tissue research}, keywords = {atherosclerosis, caveolae, caveolin-1, review, transcytosis, transport}, month = {August}, posted-at = {2008-08-26 09:44:27}, priority = {2}, title = {Caveolae and transcytosis in endothelial cells: role in atherosclerosis.}, url = {http://dx.doi.org/10.1007/s00441-008-0659-8}, year = {2008} }

TY - JOUR ID - citeulike:3154865 L3 - citeulike-article-id:3154865 N2 - The endothelium plays an important role in the regulation of molecular exchanges between the blood and peripheral tissues. The transport of molecules between tissues must be tightly controlled in order to maintain homeostasis between the different organs of the body. The endothelial transcytosis pathway has been shown to direct the transfer of proteins and solutes and therefore to act as a filtering system. This transport mode has been demonstrated to involve plasma-membrane vesicles that may be transferred with their cargo components from the apical to the basal side of endothelial cells. Among the vesicles implicated in the regulation of transcytosis, caveolae, which are 50 to 100-nm plasma-membrane invaginations, have been reported to play an essential part. In this paper, we review the function of caveolae and their major protein component (i.e., caveolin-1) in the regulation of endothelial transcytosis. The roles of caveolae in vascular diseases, such as atherosclerosis, are discussed. JF - Cell and tissue research SN - 0302-766X AD - Kimmel Cancer Center, Departments of Cancer Biology, and Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA, philippe.frank@jefferson.edu. TI - Caveolae and transcytosis in endothelial cells: role in atherosclerosis. KW - atherosclerosis KW - caveolae KW - caveolin-1 KW - review KW - transcytosis KW - transport AU - Frank, Philippe AU - Pavlides, Stephanos AU - Lisanti, Michael PY - 2008/08/08/ UR - http://dx.doi.org/10.1007/s00441-008-0659-8 ER -