Remodeling of vascular endothelial cells exposed to fluid shear stress: experimental and numerical approach Export

@article{citeulike:4198100, abstract = {Vascular endothelial cells are an interface between blood vessel walls and blood flow, and play important roles in physiological functions. Since endothelial cell responses to fluid shear stress have been implicated in the localization of atherosclerosis, the effect of shear stress on endothelial cell morphology and functions has been exclusively studied. After applying fluid shear stress, cultured endothelial cells show marked elongation and orientation in the flow direction. In addition, thick stress fibers of actin filaments appear and align along the cell long axis. Thus, the endothelial cell morphology is closely related to the cytoskeletal structure. The purpose of this review is to summarize endothelial cell responses to fluid flow which have been studied, focusing on the changes in cell shape and cytoskeletal structure. Numerical studies to simulate local flow field at the cellular level and the resulting intracellular stresses are also reviewed.}, author = {Ohashi, Toshiro and Sato, Masaaki}, citeulike-article-id = {4198100}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.fluiddyn.2004.08.005}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/S0169-5983(05)00027-4}, day = {06}, doi = {10.1016/j.fluiddyn.2004.08.005}, issn = {0169-5983}, journal = {Fluid Dynamics Research}, keywords = {actin, endothelial, mechanical, model, modeling, morphology, properties, review, shear, stiffening, theorectical}, number = {1-2}, pages = {40--59}, posted-at = {2009-03-20 14:12:59}, priority = {2}, title = {Remodeling of vascular endothelial cells exposed to fluid shear stress: experimental and numerical approach}, url = {http://dx.doi.org/10.1016/j.fluiddyn.2004.08.005}, volume = {37} }

TY - JOUR ID - citeulike:4198100 L3 - citeulike-article-id:4198100 N2 - Vascular endothelial cells are an interface between blood vessel walls and blood flow, and play important roles in physiological functions. Since endothelial cell responses to fluid shear stress have been implicated in the localization of atherosclerosis, the effect of shear stress on endothelial cell morphology and functions has been exclusively studied. After applying fluid shear stress, cultured endothelial cells show marked elongation and orientation in the flow direction. In addition, thick stress fibers of actin filaments appear and align along the cell long axis. Thus, the endothelial cell morphology is closely related to the cytoskeletal structure. The purpose of this review is to summarize endothelial cell responses to fluid flow which have been studied, focusing on the changes in cell shape and cytoskeletal structure. Numerical studies to simulate local flow field at the cellular level and the resulting intracellular stresses are also reviewed. IS - 1-2 JF - Fluid Dynamics Research SN - 0169-5983 EP - 59 TI - Remodeling of vascular endothelial cells exposed to fluid shear stress: experimental and numerical approach VL - 37 SP - 40 KW - actin KW - endothelial KW - mechanical KW - model KW - modeling KW - morphology KW - properties KW - review KW - shear KW - stiffening KW - theorectical AU - Ohashi, Toshiro AU - Sato, Masaaki UR - http://dx.doi.org/10.1016/j.fluiddyn.2004.08.005 ER -