Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning ドーパミン作働性神経細胞の一時的な（phasic）発火は行動の条件付けにおいて十分な役割を果たしている Export

@article{citeulike:4395198, abstract = {Natural rewards and drugs of abuse can alter dopamine signaling, and ventral tegmental area (VTA) dopaminergic neurons are known to fire action potentials tonically (<10 Hz) or phasically (15 to 30 Hz) under different behavioral conditions. However, without technology to control specific neurons with appropriate temporal precision in freely behaving mammals, the causal role of these action potential patterns in driving behavioral changes has been unclear. We used optogenetic tools to selectively stimulate VTA dopaminergic neuron action potential firing in freely behaving mammals. We found that phasic activation of these neurons was sufficient to drive behavioral conditioning and elicited dopamine transients with magnitudes not achieved by longer, lower-frequency spiking. These results demonstrate that phasic dopaminergic activity is sufficient to mediate mammalian behavioral conditioning. 10.1126/science.1168878 マウス深部脳の神経細胞における高周波パルス様活動電位はドーパミン放出を促進し、 報酬関連行動を惹起する。}, author = {Tsai, Hsing-Chen and Zhang, Feng and Adamantidis, Antoine and Stuber, Garret D. and Bonci, Antonello and de Lecea, Luis and Deisseroth, Karl}, citeulike-article-id = {4395198}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1168878}, citeulike-linkout-1 = {http://www.sciencemag.org/content/324/5930/1080.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/324/5930/1080.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/324/5930/1080?ijkey=22d4fd55152f39dfba4f1483cc0f3c252f725dfb}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/19389999}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=19389999}, doi = {10.1126/science.1168878}, issn = {1095-9203}, journal = {Science}, keywords = {area, behaving, behavioral, conditioning, dopamine, freely, mammal, mammalian, tegmental, ventral, vta}, month = {May}, number = {5930}, pages = {1080--1084}, posted-at = {2009-06-20 02:42:45}, priority = {2}, title = {Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning ドーパミン作働性神経細胞の一時的な（phasic）発火は行動の条件付けにおいて十分な役割を果たしている}, url = {http://dx.doi.org/10.1126/science.1168878}, volume = {324}, year = {2009} }

TY - JOUR ID - citeulike:4395198 L3 - citeulike-article-id:4395198 N2 - Natural rewards and drugs of abuse can alter dopamine signaling, and ventral tegmental area (VTA) dopaminergic neurons are known to fire action potentials tonically (<10 Hz) or phasically (15 to 30 Hz) under different behavioral conditions. However, without technology to control specific neurons with appropriate temporal precision in freely behaving mammals, the causal role of these action potential patterns in driving behavioral changes has been unclear. We used optogenetic tools to selectively stimulate VTA dopaminergic neuron action potential firing in freely behaving mammals. We found that phasic activation of these neurons was sufficient to drive behavioral conditioning and elicited dopamine transients with magnitudes not achieved by longer, lower-frequency spiking. These results demonstrate that phasic dopaminergic activity is sufficient to mediate mammalian behavioral conditioning. 10.1126/science.1168878 マウス深部脳の神経細胞における高周波パルス様活動電位はドーパミン放出を促進し、 報酬関連行動を惹起する。 IS - 5930 JF - Science SN - 1095-9203 EP - 1084 TI - Phasic Firing in Dopaminergic Neurons Is Sufficient for Behavioral Conditioning ドーパミン作働性神経細胞の一時的な（phasic）発火は行動の条件付けにおいて十分な役割を果たしている VL - 324 SP - 1080 KW - area KW - behaving KW - behavioral KW - conditioning KW - dopamine KW - freely KW - mammal KW - mammalian KW - tegmental KW - ventral KW - vta AU - Tsai, Hsing-Chen AU - Zhang, Feng AU - Adamantidis, Antoine AU - Stuber, Garret AU - Bonci, Antonello AU - de Lecea, Luis AU - Deisseroth, Karl PY - 2009/05/22/ UR - http://dx.doi.org/10.1126/science.1168878 ER -