A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation 空間パターンの区別における成体海馬神経細胞新生の機能的役割 Export

@article{citeulike:5117843, abstract = {The dentate gyrus (DG) of the mammalian hippocampus is hypothesized to mediate pattern separation--the formation of distinct and orthogonal representations of mnemonic information--and also undergoes neurogenesis throughout life. How neurogenesis contributes to hippocampal function is largely unknown. Using adult mice in which hippocampal neurogenesis was ablated, we found specific impairments in spatial discrimination with two behavioral assays: (i) a spatial navigation radial arm maze task and (ii) a spatial, but non-navigable, task in the mouse touch screen. Mice with ablated neurogenesis were impaired when stimuli were presented with little spatial separation, but not when stimuli were more widely separated in space. Thus, newborn neurons may be necessary for normal pattern separation function in the DG of adult mice. 10.1126/science.1173215 成体マウス脳の神経細胞形成部位（海馬歯状回）における神経発生を阻害すると、空間記憶の機能が傷害される。}, author = {Clelland, C. D. and Choi, M. and Romberg, C. and Clemenson, G. D. and Fragniere, A. and Tyers, P. and Jessberger, S. and Saksida, L. M. and Barker, R. A. and Gage, F. H. and Bussey, T. J.}, citeulike-article-id = {5117843}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1173215}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/325/5937/210}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19590004}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19590004}, day = {10}, doi = {10.1126/science.1173215}, issn = {1095-9203}, journal = {Science (New York, N.Y.)}, keywords = {dentate, dg, gyrus, hippocampus, mice, separation, spatial}, month = {July}, number = {5937}, pages = {210--213}, posted-at = {2009-07-15 13:44:09}, priority = {2}, title = {A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation 空間パターンの区別における成体海馬神経細胞新生の機能的役割}, url = {http://dx.doi.org/10.1126/science.1173215}, volume = {325}, year = {2009} }

TY - JOUR ID - citeulike:5117843 L3 - citeulike-article-id:5117843 N2 - The dentate gyrus (DG) of the mammalian hippocampus is hypothesized to mediate pattern separation--the formation of distinct and orthogonal representations of mnemonic information--and also undergoes neurogenesis throughout life. How neurogenesis contributes to hippocampal function is largely unknown. Using adult mice in which hippocampal neurogenesis was ablated, we found specific impairments in spatial discrimination with two behavioral assays: (i) a spatial navigation radial arm maze task and (ii) a spatial, but non-navigable, task in the mouse touch screen. Mice with ablated neurogenesis were impaired when stimuli were presented with little spatial separation, but not when stimuli were more widely separated in space. Thus, newborn neurons may be necessary for normal pattern separation function in the DG of adult mice. 10.1126/science.1173215 成体マウス脳の神経細胞形成部位（海馬歯状回）における神経発生を阻害すると、空間記憶の機能が傷害される。 IS - 5937 JF - Science (New York, N.Y.) SN - 1095-9203 EP - 213 TI - A Functional Role for Adult Hippocampal Neurogenesis in Spatial Pattern Separation 空間パターンの区別における成体海馬神経細胞新生の機能的役割 VL - 325 SP - 210 KW - dentate KW - dg KW - gyrus KW - hippocampus KW - mice KW - separation KW - spatial AU - Clelland, CD AU - Choi, M AU - Romberg, C AU - Clemenson, GD AU - Fragniere, A AU - Tyers, P AU - Jessberger, S AU - Saksida, LM AU - Barker, RA AU - Gage, FH AU - Bussey, TJ PY - 2009/07/10/ UR - http://dx.doi.org/10.1126/science.1173215 ER -