Dopamine Controls Persistence of Long-Term Memory Storage ドーパミンが長期記憶の貯蔵の持続性を調節している Export

@article{citeulike:5495397, abstract = {The paradigmatic feature of long-term memory (LTM) is its persistence. However, little is known about the mechanisms that make some LTMs last longer than others. In rats, a long-lasting fear LTM vanished rapidly when the D1 dopamine receptor antagonist SCH23390 was injected into the dorsal hippocampus 12 hours, but not immediately or 9 hours, after the fearful experience. Conversely, intrahippocampal application of the D1 agonist SK38393 at the same critical post-training time converted a rapidly decaying fear LTM into a persistent one. This effect was mediated by brain-derived neurotrophic factor and regulated by the ventral tegmental area (VTA). Thus, the persistence of LTM depends on activation of VTA/hippocampus dopaminergic connections and can be specifically modulated by manipulating this system at definite post-learning time points. 10.1126/science.1172545 （ラットを用いて、inhibitory avoidance taskに伴う恐怖の長期記憶について）薬理学的および生化学的解析を行うことにより、ドーパミンが恐怖記憶貯蔵の持続性を決めていることが明らかにされた。}, author = {Rossato, Janine I. and Bevilaqua, Lia R. M. and Izquierdo, Ivan and Medina, Jorge H. and Cammarota, Martin}, citeulike-article-id = {5495397}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1172545}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/325/5943/1017}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19696353}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19696353}, day = {21}, doi = {10.1126/science.1172545}, journal = {Science}, keywords = {agonist, antagonist, area, d1, dopamine, dorsal, hippocampus, long-term, ltm, memory, rat, receptor, tegmental, ventral, vta}, month = {August}, number = {5943}, pages = {1017--1020}, posted-at = {2009-08-31 08:33:02}, priority = {2}, title = {Dopamine Controls Persistence of Long-Term Memory Storage ドーパミンが長期記憶の貯蔵の持続性を調節している}, url = {http://dx.doi.org/10.1126/science.1172545}, volume = {325}, year = {2009} }

TY - JOUR ID - citeulike:5495397 L3 - citeulike-article-id:5495397 N2 - The paradigmatic feature of long-term memory (LTM) is its persistence. However, little is known about the mechanisms that make some LTMs last longer than others. In rats, a long-lasting fear LTM vanished rapidly when the D1 dopamine receptor antagonist SCH23390 was injected into the dorsal hippocampus 12 hours, but not immediately or 9 hours, after the fearful experience. Conversely, intrahippocampal application of the D1 agonist SK38393 at the same critical post-training time converted a rapidly decaying fear LTM into a persistent one. This effect was mediated by brain-derived neurotrophic factor and regulated by the ventral tegmental area (VTA). Thus, the persistence of LTM depends on activation of VTA/hippocampus dopaminergic connections and can be specifically modulated by manipulating this system at definite post-learning time points. 10.1126/science.1172545 （ラットを用いて、inhibitory avoidance taskに伴う恐怖の長期記憶について）薬理学的および生化学的解析を行うことにより、ドーパミンが恐怖記憶貯蔵の持続性を決めていることが明らかにされた。 IS - 5943 JF - Science EP - 1020 TI - Dopamine Controls Persistence of Long-Term Memory Storage ドーパミンが長期記憶の貯蔵の持続性を調節している VL - 325 SP - 1017 KW - agonist KW - antagonist KW - area KW - d1 KW - dopamine KW - dorsal KW - hippocampus KW - long-term KW - ltm KW - memory KW - rat KW - receptor KW - tegmental KW - ventral KW - vta AU - Rossato, Janine AU - Bevilaqua, Lia AU - Izquierdo, Ivan AU - Medina, Jorge AU - Cammarota, Martin PY - 2009/08/21/ UR - http://dx.doi.org/10.1126/science.1172545 ER -