Perineuronal Nets Protect Fear Memories from Erasure 神経細胞を覆う細胞外組織が恐怖記憶の消去を防ぐ Export

@article{citeulike:5721689, abstract = {In adult animals, fear conditioning induces a permanent memory that is resilient to erasure by extinction. In contrast, during early postnatal development, extinction of conditioned fear leads to memory erasure, suggesting that fear memories are actively protected in adults. We show here that this protection is conferred by extracellular matrix chondroitin sulfate proteoglycans (CSPGs) in the amygdala. The organization of CSPGs into perineuronal nets (PNNs) coincided with the developmental switch in fear memory resilience. In adults, degradation of PNNs by chondroitinase ABC specifically rendered subsequently acquired fear memories susceptible to erasure. This result indicates that intact PNNs mediate the formation of erasure-resistant fear memories and identifies a molecular mechanism closing a postnatal critical period during which traumatic memories can be erased by extinction. 10.1126/science.1174146 小児では消去可能な恐怖記憶が成人では消去困難になる。その理由は、脳内扁桃体のGABA含有神経細胞の周囲の生理的環境のせいである（細胞外マトリックス へコンドロイチン硫酸プロテオグリカンが取り込まれる）。}, author = {Gogolla, Nadine and Caroni, Pico and Luthi, Andreas and Herry, Cyril}, citeulike-article-id = {5721689}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.1174146}, citeulike-linkout-1 = {http://www.sciencemag.org/content/325/5945/1258.abstract}, citeulike-linkout-2 = {http://www.sciencemag.org/content/325/5945/1258.full.pdf}, citeulike-linkout-3 = {http://www.sciencemag.org/cgi/content/abstract/325/5945/1258}, citeulike-linkout-4 = {http://view.ncbi.nlm.nih.gov/pubmed/19729657}, citeulike-linkout-5 = {http://www.hubmed.org/display.cgi?uids=19729657}, day = {4}, doi = {10.1126/science.1174146}, issn = {1095-9203}, journal = {Science}, keywords = {adult, amygdala, animal, conditioning, fear, postnatal}, month = {September}, number = {5945}, pages = {1258--1261}, posted-at = {2009-09-16 01:38:55}, priority = {2}, title = {Perineuronal Nets Protect Fear Memories from Erasure 神経細胞を覆う細胞外組織が恐怖記憶の消去を防ぐ}, url = {http://dx.doi.org/10.1126/science.1174146}, volume = {325}, year = {2009} }

TY - JOUR ID - citeulike:5721689 L3 - citeulike-article-id:5721689 N2 - In adult animals, fear conditioning induces a permanent memory that is resilient to erasure by extinction. In contrast, during early postnatal development, extinction of conditioned fear leads to memory erasure, suggesting that fear memories are actively protected in adults. We show here that this protection is conferred by extracellular matrix chondroitin sulfate proteoglycans (CSPGs) in the amygdala. The organization of CSPGs into perineuronal nets (PNNs) coincided with the developmental switch in fear memory resilience. In adults, degradation of PNNs by chondroitinase ABC specifically rendered subsequently acquired fear memories susceptible to erasure. This result indicates that intact PNNs mediate the formation of erasure-resistant fear memories and identifies a molecular mechanism closing a postnatal critical period during which traumatic memories can be erased by extinction. 10.1126/science.1174146 小児では消去可能な恐怖記憶が成人では消去困難になる。その理由は、脳内扁桃体のGABA含有神経細胞の周囲の生理的環境のせいである（細胞外マトリックス へコンドロイチン硫酸プロテオグリカンが取り込まれる）。 IS - 5945 JF - Science SN - 1095-9203 EP - 1261 TI - Perineuronal Nets Protect Fear Memories from Erasure 神経細胞を覆う細胞外組織が恐怖記憶の消去を防ぐ VL - 325 SP - 1258 KW - adult KW - amygdala KW - animal KW - conditioning KW - fear KW - postnatal AU - Gogolla, Nadine AU - Caroni, Pico AU - Luthi, Andreas AU - Herry, Cyril PY - 2009/09/04/ UR - http://dx.doi.org/10.1126/science.1174146 ER -