Adult-Born Hippocampal Dentate Granule Cells Undergoing Maturation Modulate Learning and Memory in the Brain Export

@article{citeulike:6076965, abstract = {Adult-born dentate granule cells (DGCs) contribute to learning and memory, yet it remains unknown when adult-born DGCs become involved in the cognitive processes. During neurogenesis, immature DGCs display distinctive physiological characteristics while undergoing morphological maturation before final integration into the neural circuits. The survival and activity of the adult-born DGCs can be influenced by the experience of the animal during a critical period when newborn DGCs are still immature. To assess the temporal importance of adult neurogenesis, we developed a transgenic mouse model that allowed us to transiently reduce the numbers of adult-born DGCs in a temporally regulatable manner. We found that mice with a reduced population of adult-born DGCs at the immature stage were deficient in forming robust, long-term spatial memory and displayed impaired performance in extinction tasks. These results suggest that immature DGCs that undergo maturation make important contributions to learning and memory. 10.1523/JNEUROSCI.3362-09.2009}, author = {Deng, Wei and Saxe, Michael D. and Gallina, Iryna S. and Gage, Fred H.}, citeulike-article-id = {6076965}, citeulike-linkout-0 = {http://dx.doi.org/10.1523/JNEUROSCI.3362-09.2009}, citeulike-linkout-1 = {http://www.jneurosci.org/content/29/43/13532.abstract}, citeulike-linkout-2 = {http://www.jneurosci.org/content/29/43/13532.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19864566}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19864566}, day = {28}, doi = {10.1523/JNEUROSCI.3362-09.2009}, journal = {J. Neurosci.}, keywords = {learning\_and\_memory, neurogenesis}, month = {October}, number = {43}, pages = {13532--13542}, posted-at = {2009-11-09 11:15:54}, priority = {2}, title = {Adult-Born Hippocampal Dentate Granule Cells Undergoing Maturation Modulate Learning and Memory in the Brain}, url = {http://dx.doi.org/10.1523/JNEUROSCI.3362-09.2009}, volume = {29}, year = {2009} }

TY - JOUR ID - citeulike:6076965 L3 - citeulike-article-id:6076965 N2 - Adult-born dentate granule cells (DGCs) contribute to learning and memory, yet it remains unknown when adult-born DGCs become involved in the cognitive processes. During neurogenesis, immature DGCs display distinctive physiological characteristics while undergoing morphological maturation before final integration into the neural circuits. The survival and activity of the adult-born DGCs can be influenced by the experience of the animal during a critical period when newborn DGCs are still immature. To assess the temporal importance of adult neurogenesis, we developed a transgenic mouse model that allowed us to transiently reduce the numbers of adult-born DGCs in a temporally regulatable manner. We found that mice with a reduced population of adult-born DGCs at the immature stage were deficient in forming robust, long-term spatial memory and displayed impaired performance in extinction tasks. These results suggest that immature DGCs that undergo maturation make important contributions to learning and memory. 10.1523/JNEUROSCI.3362-09.2009 IS - 43 JF - J. Neurosci. EP - 13542 TI - Adult-Born Hippocampal Dentate Granule Cells Undergoing Maturation Modulate Learning and Memory in the Brain VL - 29 SP - 13532 KW - learning_and_memory KW - neurogenesis AU - Deng, Wei AU - Saxe, Michael AU - Gallina, Iryna AU - Gage, Fred PY - 2009/10/28/ UR - http://dx.doi.org/10.1523/JNEUROSCI.3362-09.2009 ER -