Dynamic changes in optic fiber terminal arbors lead to retinotopic map formation: An in vivo confocal microscopic study Export

@article{citeulike:6081026, abstract = {Dynamic remodeling of retinal ganglion cell terminal arbors has been proposed to contribute to formation of the topographically ordered retinotectal projection. To test this directly, the growth of individual terminal arbors was observed in live X. laevis tadpoles using a confocal microscope to visualize their complex three-dimensional structure. During initial development, nasal and temporal retinal arbors covered overlapping tectal areas. Despite subsequent remodeling, the dimensions and positions of the temporal arbors remained relatively stable. In contrast, the nasal arbors grew caudally, as they extended caudal branches and retracted rostral branches. These results suggest that differences in the remodeling of the nasal and temporal arbors lead to the emergence of retino-topography along the rostrocaudal axis of the tectum. All the terminal arbors were dynamic, including those with stable dimensions, suggesting that continual remodeling of arbors may be a universal feature of neuronal projections.}, author = {O'Rourke, N.}, citeulike-article-id = {6081026}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/0896-6273(90)90306-Z}, citeulike-linkout-1 = {http://linkinghub.elsevier.com/retrieve/pii/0896-6273(90)90306-Z}, doi = {10.1016/0896-6273(90)90306-Z}, issn = {08966273}, journal = {Neuron}, keywords = {axon\_growth, topographic\_map, xenopus}, month = {August}, number = {2}, pages = {159--171}, posted-at = {2009-11-06 15:00:23}, priority = {2}, title = {Dynamic changes in optic fiber terminal arbors lead to retinotopic map formation: An in vivo confocal microscopic study}, url = {http://dx.doi.org/10.1016/0896-6273(90)90306-Z}, volume = {5}, year = {1990} }

TY - JOUR ID - citeulike:6081026 L3 - citeulike-article-id:6081026 N2 - Dynamic remodeling of retinal ganglion cell terminal arbors has been proposed to contribute to formation of the topographically ordered retinotectal projection. To test this directly, the growth of individual terminal arbors was observed in live X. laevis tadpoles using a confocal microscope to visualize their complex three-dimensional structure. During initial development, nasal and temporal retinal arbors covered overlapping tectal areas. Despite subsequent remodeling, the dimensions and positions of the temporal arbors remained relatively stable. In contrast, the nasal arbors grew caudally, as they extended caudal branches and retracted rostral branches. These results suggest that differences in the remodeling of the nasal and temporal arbors lead to the emergence of retino-topography along the rostrocaudal axis of the tectum. All the terminal arbors were dynamic, including those with stable dimensions, suggesting that continual remodeling of arbors may be a universal feature of neuronal projections. IS - 2 JF - Neuron SN - 08966273 EP - 171 TI - Dynamic changes in optic fiber terminal arbors lead to retinotopic map formation: An in vivo confocal microscopic study VL - 5 SP - 159 KW - axon_growth KW - topographic_map KW - xenopus AU - O'Rourke, N PY - 1990/08// UR - http://dx.doi.org/10.1016/0896-6273(90)90306-Z ER -