ulfliebal's Zhang:S [2 articles]

Abstract

RsbT is an essential component of the pathway that activates the Bacillus subtilis sigmaB transcription factor in response to physical stress. rsbT is located within an operon that includes the genes for its principal negative regulator (RsbS) and the stress pathway component that it activates (RsbU), as immediate upstream and downstream neighbors. In the current work we demonstrate that RsbT's ability to function is strongly influenced by coexpression with these adjoining genes. When rsbT is expressed at a site displaced from ...

Abstract

The general stress regulon of Bacillus subtilis is induced by activation of the sigmaB transcription factor. sigmaB activation occurs when one of two phosphatases responds to physical or nutritional stress to activate a positive sigmaB regulator by dephosphorylation. The signal that triggers the nutritional stress phosphatase (RsbP) is unknown; however, RsbP activation occurs under culture conditions (glucose/phosphate starvation, azide or decoyinine treatment) that reduce the cell's levels of ATP and/or GTP. Variances in nucleotide levels in these instances may be coincidental ...