Nuclear lipids: new functions for old molecules? Export

@article{citeulike:1178287, abstract = {It is becoming increasingly evident that stimulation of nuclear lipid metabolism plays a central role in many signal transduction pathways that ultimately result in various cell responses including proliferation and differentiation. Nuclear lipid metabolism seems to be at least as complex as that existing at the plasma membrane. However, a distinctive feature of nuclear lipid biochemical pathways is their operational independence from their cell periphery counterparts. Although initially it was thought that nuclear lipids would serve as a source for second messengers, recent evidence points to the likelihood that lipids present in the nucleus also fulfil other roles. The aim of this review is to highlight the most intriguing advances made in the field over the last year, such as the production of new probes for the in situ mapping of nuclear phosphoinositides, the identification of two sources for nuclear diacylglycerol production, the emerging details about the peculiar regulation of nuclear phosphoinositide synthesizing enzymes, and the distinct possibility that nuclear lipids are involved in processes such as chromatin organization and pre-mRNA splicing.}, address = {Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell'Apparato Locomotore, Sezione di Anatomia, Cell Signaling Laboratory, Universit\`{a} di Bologna, Via Irnerio 48, Italy. amartell@biocfarm.unibo.it}, author = {Martelli, A. M. and Tabellini, G. and Borgatti, P. and Bortul, R. and Capitani, S. and Neri, L. M.}, citeulike-article-id = {1178287}, citeulike-linkout-0 = {http://dx.doi.org/10.1002/jcb.10379}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/12532322}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=12532322}, day = {15}, doi = {10.1002/jcb.10379}, issn = {0730-2312}, journal = {J Cell Biochem}, keywords = {chromatin, chromatin\_structure, lipid, nuclear\_lipid, nucleus, review}, month = {February}, number = {3}, pages = {455--461}, posted-at = {2007-03-20 19:17:56}, priority = {2}, title = {Nuclear lipids: new functions for old molecules?}, url = {http://dx.doi.org/10.1002/jcb.10379}, volume = {88}, year = {2003} }

TY - JOUR ID - citeulike:1178287 L3 - citeulike-article-id:1178287 N2 - It is becoming increasingly evident that stimulation of nuclear lipid metabolism plays a central role in many signal transduction pathways that ultimately result in various cell responses including proliferation and differentiation. Nuclear lipid metabolism seems to be at least as complex as that existing at the plasma membrane. However, a distinctive feature of nuclear lipid biochemical pathways is their operational independence from their cell periphery counterparts. Although initially it was thought that nuclear lipids would serve as a source for second messengers, recent evidence points to the likelihood that lipids present in the nucleus also fulfil other roles. The aim of this review is to highlight the most intriguing advances made in the field over the last year, such as the production of new probes for the in situ mapping of nuclear phosphoinositides, the identification of two sources for nuclear diacylglycerol production, the emerging details about the peculiar regulation of nuclear phosphoinositide synthesizing enzymes, and the distinct possibility that nuclear lipids are involved in processes such as chromatin organization and pre-mRNA splicing. IS - 3 JF - J Cell Biochem SN - 0730-2312 AD - Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell'Apparato Locomotore, Sezione di Anatomia, Cell Signaling Laboratory, Università di Bologna, Via Irnerio 48, Italy. amartell@biocfarm.unibo.it EP - 461 TI - Nuclear lipids: new functions for old molecules? VL - 88 SP - 455 KW - chromatin KW - chromatin_structure KW - lipid KW - nuclear_lipid KW - nucleus KW - review AU - Martelli, AM AU - Tabellini, G AU - Borgatti, P AU - Bortul, R AU - Capitani, S AU - Neri, LM PY - 2003/02/15/ UR - http://dx.doi.org/10.1002/jcb.10379 ER -