Role of glutathione in cellular resistance to alkylating agents Export

@article{citeulike:1180952, abstract = {Both elevated glutathione levels and increased activity of the enzyme glutathione S-transferase have been associated with the resistance of cells to alkylating agents. We have demonstrated that one mechanism of this resistance is the inactivation of the alkylating agents by conjugation with glutathione. This conjugation can be catalyzed by glutathione S-transferase. For the nitrogen mustard agents we have studied, both the spontaneous and enzyme catalyzed reactions proceed through the aziridinium intermediates of the alkylating agents, and the [alpha] isoenzymes of GST are involved. In a study of cyclophosphamide resistant medulloblastoma cell lines elevated cellular concentrations of glutathione correlated well with the resistance of the cell lines.}, author = {Colvin, Michael O. and Friedman, Henry S. and Gamcsik, Michael P. and Fenselau, Catherine and Hilton, John}, citeulike-article-id = {1180952}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/0065-2571(93)90006-Y}, citeulike-linkout-1 = {http://www.sciencedirect.com/science/article/B6T3T-478HNF8-3G/2/0d099c045f0bf2577267e8f9507e8979}, doi = {10.1016/0065-2571(93)90006-Y}, journal = {Advances in Enzyme Regulation}, keywords = {alkylating\_agents, alkylation, cyclophosphamide, glutathione, review}, pages = {19--26}, posted-at = {2007-03-22 17:49:14}, priority = {2}, title = {Role of glutathione in cellular resistance to alkylating agents}, url = {http://dx.doi.org/10.1016/0065-2571(93)90006-Y}, volume = {33}, year = {1993} }

TY - JOUR ID - citeulike:1180952 L3 - citeulike-article-id:1180952 N2 - Both elevated glutathione levels and increased activity of the enzyme glutathione S-transferase have been associated with the resistance of cells to alkylating agents. We have demonstrated that one mechanism of this resistance is the inactivation of the alkylating agents by conjugation with glutathione. This conjugation can be catalyzed by glutathione S-transferase. For the nitrogen mustard agents we have studied, both the spontaneous and enzyme catalyzed reactions proceed through the aziridinium intermediates of the alkylating agents, and the [alpha] isoenzymes of GST are involved. In a study of cyclophosphamide resistant medulloblastoma cell lines elevated cellular concentrations of glutathione correlated well with the resistance of the cell lines. JF - Advances in Enzyme Regulation EP - 26 TI - Role of glutathione in cellular resistance to alkylating agents VL - 33 SP - 19 KW - alkylating_agents KW - alkylation KW - cyclophosphamide KW - glutathione KW - review AU - Colvin, Michael AU - Friedman, Henry AU - Gamcsik, Michael AU - Fenselau, Catherine AU - Hilton, John PY - 1993/// UR - http://dx.doi.org/10.1016/0065-2571(93)90006-Y ER -