Chromatin structure and de novo methylation of sperm DNA: implications for activation of the paternal genome. Export

@article{citeulike:1293164, abstract = {The chromatin structure characteristic of constitutively expressed genes, tissue-specific genes, and inactive genes is absent in chicken sperm chromatin. However, point sites of undermethylation in sperm DNA within constitutively expressed genes, but not within globin genes or an inactive gene, correspond to the location of regions of altered chromatin structure (hypersensitive sites) in somatic tissue and spermatogonial cells. A de novo methylation process whereby regions within and flanking these genes become methylated, but which excludes the methylation of sequences within hypersensitive sites, occurs between the spermatogonial stage and the first meiotic prophase. These undermethylated regions may play a role in the activation of the paternal genome during embryogenesis.}, author = {Groudine, M. and Conkin, K. F.}, citeulike-article-id = {1293164}, citeulike-linkout-0 = {http://dx.doi.org/10.1126/science.2986289}, citeulike-linkout-1 = {http://www.sciencemag.org/cgi/content/abstract/228/4703/1061}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/2986289}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=2986289}, day = {31}, doi = {10.1126/science.2986289}, issn = {0036-8075}, journal = {Science}, keywords = {chromatin, chromatin\_structure, dna\_methylation, paternal\_genome, spermatozoa}, month = {May}, number = {4703}, pages = {1061--1068}, posted-at = {2007-05-14 03:41:24}, priority = {4}, title = {Chromatin structure and de novo methylation of sperm DNA: implications for activation of the paternal genome.}, url = {http://dx.doi.org/10.1126/science.2986289}, volume = {228}, year = {1985} }

TY - JOUR ID - citeulike:1293164 L3 - citeulike-article-id:1293164 N2 - The chromatin structure characteristic of constitutively expressed genes, tissue-specific genes, and inactive genes is absent in chicken sperm chromatin. However, point sites of undermethylation in sperm DNA within constitutively expressed genes, but not within globin genes or an inactive gene, correspond to the location of regions of altered chromatin structure (hypersensitive sites) in somatic tissue and spermatogonial cells. A de novo methylation process whereby regions within and flanking these genes become methylated, but which excludes the methylation of sequences within hypersensitive sites, occurs between the spermatogonial stage and the first meiotic prophase. These undermethylated regions may play a role in the activation of the paternal genome during embryogenesis. IS - 4703 JF - Science SN - 0036-8075 EP - 1068 TI - Chromatin structure and de novo methylation of sperm DNA: implications for activation of the paternal genome. VL - 228 SP - 1061 KW - chromatin KW - chromatin_structure KW - dna_methylation KW - paternal_genome KW - spermatozoa AU - Groudine, M AU - Conkin, KF PY - 1985/05/31/ UR - http://dx.doi.org/10.1126/science.2986289 ER -