New insights into the molecular mechanisms of sperm-egg interaction.

@article{citeulike:1449566, abstract = {At the moment of insemination millions of mammalian sperm cells are released into the female reproductive tract in order to find a single cell - the oocyte. The spermatozoa subsequently ignore the thousands of cells they make contact with during their journey to the site of fertilisation, until they reach the surface of the oocyte. At this point, they bind tenaciously to the acellular coat, known as the zona pellucida, that surrounds the oocyte and initiate the chain of cellular interactions that will culminate in fertilization. These exquisitely cell- and species-specific recognition events are among the most strategically important cellular interactions in biology. Understanding the cellular and molecular mechanisms that underpin them has implications for diagnosis of the aetiology of human infertility and the development of novel targets for fertility regulation. Herein, we describe two models indicating the plethora of highly orchestrated molecular interactions underlying successful sperm zona binding and sperm oocyte fusion.}, address = {Reproductive Science Group, ARC Centre of Excellence in Biotechnology \& Development, School of Environmental \& Life Sciences, University of Newcastle, Callaghan, NSW, 2308, Australia.}, author = {Nixon, B and Aitken, R J. and McLaughlin, E A.}, citeulike-article-id = {1449566}, doi = {10.1007/s00018-007-6552-x}, issn = {1420-682X}, journal = {Cell Mol Life Sci}, keywords = {oocyte, review, sperm-egg\_interaction, spermatozoa, zona\_pellucida}, month = {April}, posted-at = {2007-07-11 16:55:05}, priority = {2}, title = {New insights into the molecular mechanisms of sperm-egg interaction.}, url = {http://dx.doi.org/10.1007/s00018-007-6552-x}, year = {2007} }

TY - JOUR ID - citeulike:1449566 L3 - citeulike-article-id:1449566 N2 - At the moment of insemination millions of mammalian sperm cells are released into the female reproductive tract in order to find a single cell - the oocyte. The spermatozoa subsequently ignore the thousands of cells they make contact with during their journey to the site of fertilisation, until they reach the surface of the oocyte. At this point, they bind tenaciously to the acellular coat, known as the zona pellucida, that surrounds the oocyte and initiate the chain of cellular interactions that will culminate in fertilization. These exquisitely cell- and species-specific recognition events are among the most strategically important cellular interactions in biology. Understanding the cellular and molecular mechanisms that underpin them has implications for diagnosis of the aetiology of human infertility and the development of novel targets for fertility regulation. Herein, we describe two models indicating the plethora of highly orchestrated molecular interactions underlying successful sperm zona binding and sperm oocyte fusion. JF - Cell Mol Life Sci SN - 1420-682X AD - Reproductive Science Group, ARC Centre of Excellence in Biotechnology & Development, School of Environmental & Life Sciences, University of Newcastle, Callaghan, NSW, 2308, Australia. TI - New insights into the molecular mechanisms of sperm-egg interaction. KW - oocyte KW - review KW - sperm-egg_interaction KW - spermatozoa KW - zona_pellucida AU - Nixon, B AU - Aitken, R AU - McLaughlin, E PY - 2007/04/20/ UR - http://dx.doi.org/10.1007/s00018-007-6552-x ER -