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Nature, Vol. 408, No. 6811. (23 November 2000), pp. 433-439, doi:10.1038/35044005 Key: citeulike:4014342
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The inability to repair DNA damage properly in mammals leads to various disorders and enhanced rates of tumour development. Organisms respond to chromosomal insults by activating a complex damage response pathway. This pathway regulates known responses such as cell-cycle arrest and apoptosis (programmed cell death), and has recently been shown to control additional processes including direct activation of DNA repair networks.
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