Hemodynamics in the mouse aortic arch as assessed by MRI, ultrasound, and numerical modeling Export

@article{feintuch2007, abstract = {Mice are widely used to study arterial disease in humans, and the pathogenesis of arterial diseases is known to be strongly influenced by hemodynamic factors. It is, therefore, of interest to characterize the hemodynamic environment in the mouse arterial tree. Previous measurements have suggested that many relevant hemodynamic variables are similar between the mouse and the human. Here we use a combination of Doppler ultrasound and MRI measurements, coupled with numerical modeling techniques, to characterize the hemodynamic environment in the mouse aortic arch at high spatial resolution. We find that the hemodynamically induced stresses on arterial endothelial cells are much larger in magnitude and more spatially uniform in the mouse than in the human, an effect that can be explained by fluid mechanical scaling principles. This surprising finding seems to be at variance with currently accepted models of the role of hemodynamics in atherogenesis and the known distribution of atheromatous lesions in mice.}, author = {Feintuch, Akiva and Ruengsakulrach, Permyos and Lin, Amy and Zhang, Ji and Zhou, Yu Q. and Bishop, Jonathon and Davidson, Lorinda and Courtman, David and Foster, Stuart F. and Steinman, David A. and Henkelman, Mark R. and Ethier, Ross C.}, citeulike-article-id = {2334798}, eprint = {http://ajpheart.physiology.org/cgi/reprint/292/2/H884.pdf}, journal = {Am J Physiol Heart Circ Physiol}, keywords = {aorta, flow, imaging, mouse, mri, numerical, secondaryflow, ultrasound, unsteady, wss}, number = {2}, pages = {H884--892}, pdf = {feintuch2007.pdf}, posted-at = {2008-02-05 13:12:51}, priority = {0}, title = {{Hemodynamics in the mouse aortic arch as assessed by MRI, ultrasound, and numerical modeling}}, volume = {292}, year = {2007} }

TY - JOUR ID - feintuch2007 L3 - citeulike-article-id:2334798 N2 - Mice are widely used to study arterial disease in humans, and the pathogenesis of arterial diseases is known to be strongly influenced by hemodynamic factors. It is, therefore, of interest to characterize the hemodynamic environment in the mouse arterial tree. Previous measurements have suggested that many relevant hemodynamic variables are similar between the mouse and the human. Here we use a combination of Doppler ultrasound and MRI measurements, coupled with numerical modeling techniques, to characterize the hemodynamic environment in the mouse aortic arch at high spatial resolution. We find that the hemodynamically induced stresses on arterial endothelial cells are much larger in magnitude and more spatially uniform in the mouse than in the human, an effect that can be explained by fluid mechanical scaling principles. This surprising finding seems to be at variance with currently accepted models of the role of hemodynamics in atherogenesis and the known distribution of atheromatous lesions in mice. IS - 2 JF - Am J Physiol Heart Circ Physiol EP - 892 TI - {Hemodynamics in the mouse aortic arch as assessed by MRI, ultrasound, and numerical modeling} VL - 292 SP - H884 KW - aorta KW - flow KW - imaging KW - mouse KW - mri KW - numerical KW - secondaryflow KW - ultrasound KW - unsteady KW - wss AU - Feintuch, Akiva AU - Ruengsakulrach, Permyos AU - Lin, Amy AU - Zhang, Ji AU - Zhou, Yu AU - Bishop, Jonathon AU - Davidson, Lorinda AU - Courtman, David AU - Foster, Stuart AU - Steinman, David AU - Henkelman, Mark AU - Ethier, Ross PY - 2007/// ER -