Coupling of Navier-Stokes equations with protein molecular dynamics and its application to hemodynamics Export

@article{liu2004, abstract = {The red blood cell (RBC) aggregation plays an important role in many physiological phenomena, in particular the atherosclerosis and thrombotic processes. In this research, we introduce a new modelling technique that couples Navier-Stokes equations with protein molecular dynamics to investigate the behaviours of RBC aggregates and their effects on the blood rheology. In essence, the Lagrangian solid mesh, which represents the immersed deformable cells, is set to move on top of a background Eulerian mesh. The effects of cell-cell interaction (adhesive/repulsive) and hydrodynamic forces on RBC aggregates are studied by introducing equivalent protein molecular potentials into the immersed finite element method. The aggregation of red blood cells in quiescent fluids is simulated. The de-aggregation of a RBC cluster at different shear rates is also investigated to provide an explanation of the shear-rate-dependence of the blood viscoelastic properties. Finally, the influences of cell-cell interaction, RBC rigidity, and vessel geometry are addressed in a series of test cases with deformable cells (normal and sickle RBCs) passing through micro- and capillary vessels. Copyright \© 2004 John Wiley and Sons, Ltd.}, author = {Liu, Y. and Zhang, L. and Wang, X. and Liu, W. K.}, citeulike-article-id = {2334830}, comment = {Red blood cells (RBC);Molecular potentials;Blood rheology;Vessel geometry;}, journal = {International Journal for Numerical Methods in Fluids}, key = {Navier Stokes equations}, keywords = {flow, fsi, numerical, rbc, wss}, number = {12}, pdf = {liu2004.pdf}, posted-at = {2008-02-05 13:12:53}, priority = {0}, title = {Coupling of {Navier-Stokes} equations with protein molecular dynamics and its application to hemodynamics}, volume = {46}, year = {2004} }

TY - JOUR ID - liu2004 L3 - citeulike-article-id:2334830 N2 - The red blood cell (RBC) aggregation plays an important role in many physiological phenomena, in particular the atherosclerosis and thrombotic processes. In this research, we introduce a new modelling technique that couples Navier-Stokes equations with protein molecular dynamics to investigate the behaviours of RBC aggregates and their effects on the blood rheology. In essence, the Lagrangian solid mesh, which represents the immersed deformable cells, is set to move on top of a background Eulerian mesh. The effects of cell-cell interaction (adhesive/repulsive) and hydrodynamic forces on RBC aggregates are studied by introducing equivalent protein molecular potentials into the immersed finite element method. The aggregation of red blood cells in quiescent fluids is simulated. The de-aggregation of a RBC cluster at different shear rates is also investigated to provide an explanation of the shear-rate-dependence of the blood viscoelastic properties. Finally, the influences of cell-cell interaction, RBC rigidity, and vessel geometry are addressed in a series of test cases with deformable cells (normal and sickle RBCs) passing through micro- and capillary vessels. Copyright © 2004 John Wiley and Sons, Ltd. IS - 12 JF - International Journal for Numerical Methods in Fluids TI - Coupling of {Navier-Stokes} equations with protein molecular dynamics and its application to hemodynamics VL - 46 KW - flow KW - fsi KW - numerical KW - rbc KW - wss N1 - Red blood cells (RBC);Molecular potentials;Blood rheology;Vessel geometry; AU - Liu, Y AU - Zhang, L AU - Wang, X AU - Liu, WK PY - 2004/// ER -