Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells Export

@article{citeulike:6064567, abstract = {10.1098/rstb.2006.2017 Conceptual and technical advances in neural stem cell biology are being applied to the study of human brain tumours. These studies suggest that human brain tumours are organized as a hierarchy and are maintained by a small number of tumour cells that have stem cell properties. Most of the bulk population of human brain tumours comprise cells that have lost the ability to initiate and maintain tumour growth. Although the cell of origin for human brain tumours is uncertain, recent evidence points towards the brain's known proliferative zones. The identification of brain tumour stem cells has important implications for understanding brain tumour biology and these cells may be critical cellular targets for curative therapy.}, author = {Dirks, Peter B.}, citeulike-article-id = {6064567}, citeulike-linkout-0 = {http://dx.doi.org/10.1098/rstb.2006.2017}, citeulike-linkout-1 = {http://rstb.royalsocietypublishing.org/content/363/1489/139.abstract}, citeulike-linkout-2 = {http://rstb.royalsocietypublishing.org/content/363/1489/139.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/17309866}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=17309866}, day = {12}, doi = {10.1098/rstb.2006.2017}, journal = {Philosophical Transactions of the Royal Society B: Biological Sciences}, keywords = {brain\_cancer, essay, neural\_stem\_cells, neurogenesis}, month = {January}, number = {1489}, pages = {139--152}, posted-at = {2009-11-03 21:13:46}, priority = {2}, title = {Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells}, url = {http://dx.doi.org/10.1098/rstb.2006.2017}, volume = {363}, year = {2008} }

TY - JOUR ID - citeulike:6064567 L3 - citeulike-article-id:6064567 N2 - 10.1098/rstb.2006.2017 Conceptual and technical advances in neural stem cell biology are being applied to the study of human brain tumours. These studies suggest that human brain tumours are organized as a hierarchy and are maintained by a small number of tumour cells that have stem cell properties. Most of the bulk population of human brain tumours comprise cells that have lost the ability to initiate and maintain tumour growth. Although the cell of origin for human brain tumours is uncertain, recent evidence points towards the brain's known proliferative zones. The identification of brain tumour stem cells has important implications for understanding brain tumour biology and these cells may be critical cellular targets for curative therapy. IS - 1489 JF - Philosophical Transactions of the Royal Society B: Biological Sciences EP - 152 TI - Brain tumour stem cells: the undercurrents of human brain cancer and their relationship to neural stem cells VL - 363 SP - 139 KW - brain_cancer KW - essay KW - neural_stem_cells KW - neurogenesis AU - Dirks, Peter PY - 2008/01/12/ UR - http://dx.doi.org/10.1098/rstb.2006.2017 ER -