The relation between extracellular potassium concentration and pH in the border zone during regional ischemia in isolated porcine hearts. Export

@article{citeulike:681828, abstract = {During regional ischemia gradients of extracellular potassium concentration ([K+]o) and extracellular pH (pHo) exist. In globally ischemic papillary muscles increased PCO2 causes a rise in [K+]o. We studied whether pHo and [K+]o are causally related during acute regional ischemia in the isolated blood-perfused pig heart. Multiple pH- or K(+)-sensitive electrodes were inserted in the left ventricular midmyocardium. Local electrograms and ionic data were simultaneously acquired. Regional ischemia was produced by interrupting left anterior descending (LAD) artery flow (10 min). Up to 5 mm from the electrophysiological border the pH-K relation deviated from that in the central ischemic zone. Respiratory acidosis (pH about 7.10) of the perfusate in the presence of LAD-ischemia caused acidification of the ischemic border zone without a local change in [K+]o. We conclude that pHo changes are not related to changes of intramural [K+]o in the lateral border zone during regional ischemia.}, address = {Department of Experimental Cardiology, Academic Medical Centre, Amsterdam, The Netherlands.}, author = {Coronel, R. and Wilms-Schopman, F. J. and Fiolet, J. W. and Opthof, T. and Janse, M. J.}, citeulike-article-id = {681828}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/8523466}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=8523466}, issn = {0022-2828}, journal = {J Mol Cell Cardiol}, keywords = {border, ischemic, zone}, month = {September}, number = {9}, pages = {2069--2073}, posted-at = {2006-06-02 17:52:18}, priority = {2}, title = {The relation between extracellular potassium concentration and pH in the border zone during regional ischemia in isolated porcine hearts.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/8523466}, volume = {27}, year = {1995} }

TY - JOUR ID - citeulike:681828 L3 - citeulike-article-id:681828 N2 - During regional ischemia gradients of extracellular potassium concentration ([K+]o) and extracellular pH (pHo) exist. In globally ischemic papillary muscles increased PCO2 causes a rise in [K+]o. We studied whether pHo and [K+]o are causally related during acute regional ischemia in the isolated blood-perfused pig heart. Multiple pH- or K(+)-sensitive electrodes were inserted in the left ventricular midmyocardium. Local electrograms and ionic data were simultaneously acquired. Regional ischemia was produced by interrupting left anterior descending (LAD) artery flow (10 min). Up to 5 mm from the electrophysiological border the pH-K relation deviated from that in the central ischemic zone. Respiratory acidosis (pH about 7.10) of the perfusate in the presence of LAD-ischemia caused acidification of the ischemic border zone without a local change in [K+]o. We conclude that pHo changes are not related to changes of intramural [K+]o in the lateral border zone during regional ischemia. IS - 9 JF - J Mol Cell Cardiol SN - 0022-2828 AD - Department of Experimental Cardiology, Academic Medical Centre, Amsterdam, The Netherlands. EP - 2073 TI - The relation between extracellular potassium concentration and pH in the border zone during regional ischemia in isolated porcine hearts. VL - 27 SP - 2069 KW - border KW - ischemic KW - zone AU - Coronel, R AU - Wilms-Schopman, FJ AU - Fiolet, JW AU - Opthof, T AU - Janse, MJ PY - 1995/09// UR - http://view.ncbi.nlm.nih.gov/pubmed/8523466 ER -