Extracellular pH and tension during ischemia in the isolated rabbit ventricle. Export

@article{citeulike:681876, abstract = {To investigate the factors determining the rate of H+ accumulation during early ischemia, miniature intramyocardial pH electrodes (tip diam 0.2-0.5 mm) were used to record extracellular pH (pHo) in the isolated arterially perfused rabbit interventricular septum. Changes in pHo and the rate of fall of tension during global ischemia were compared under control conditions (37 degrees C, heart rate 75 beats/min) and after exposure to the following interventions: reduced heart rate (36 beats/min), hypothermia (27 degrees C), verapamil (0.5 microM), reduced extracellular Ca2+ concentration [( Ca2+]o 0.5 mM), norepinephrine (0.5 microM) in normal and catecholamine-depleted preparations, norepinephrine and reduced [Ca2+]o, and theophylline (4 mM). Under control conditions pHo declined by 0.61-0.73 pH units after 10 min of ischemia. The negative inotropic interventions and reduced temperature significantly decreased [H+]o accumulation during ischemia. Positive inotropic interventions did not affect the rate of [H+]o accumulation during ischemia except in reserpinized preparations. All of the interventions except for reduced temperature significantly altered the relationship between tension and pHo during ischemia.}, author = {Couper, G. S. and Weiss, J. and Hiltbrand, B. and Shine, K. I.}, citeulike-article-id = {681876}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/6507639}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=6507639}, issn = {0002-9513}, journal = {Am J Physiol}, keywords = {force, ph}, month = {December}, number = {6 Pt 2}, posted-at = {2006-06-02 18:10:53}, priority = {2}, title = {Extracellular pH and tension during ischemia in the isolated rabbit ventricle.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/6507639}, volume = {247}, year = {1984} }

TY - JOUR ID - citeulike:681876 L3 - citeulike-article-id:681876 N2 - To investigate the factors determining the rate of H+ accumulation during early ischemia, miniature intramyocardial pH electrodes (tip diam 0.2-0.5 mm) were used to record extracellular pH (pHo) in the isolated arterially perfused rabbit interventricular septum. Changes in pHo and the rate of fall of tension during global ischemia were compared under control conditions (37 degrees C, heart rate 75 beats/min) and after exposure to the following interventions: reduced heart rate (36 beats/min), hypothermia (27 degrees C), verapamil (0.5 microM), reduced extracellular Ca2+ concentration [( Ca2+]o 0.5 mM), norepinephrine (0.5 microM) in normal and catecholamine-depleted preparations, norepinephrine and reduced [Ca2+]o, and theophylline (4 mM). Under control conditions pHo declined by 0.61-0.73 pH units after 10 min of ischemia. The negative inotropic interventions and reduced temperature significantly decreased [H+]o accumulation during ischemia. Positive inotropic interventions did not affect the rate of [H+]o accumulation during ischemia except in reserpinized preparations. All of the interventions except for reduced temperature significantly altered the relationship between tension and pHo during ischemia. IS - 6 Pt 2 JF - Am J Physiol SN - 0002-9513 TI - Extracellular pH and tension during ischemia in the isolated rabbit ventricle. VL - 247 KW - force KW - ph AU - Couper, GS AU - Weiss, J AU - Hiltbrand, B AU - Shine, KI PY - 1984/12// UR - http://view.ncbi.nlm.nih.gov/pubmed/6507639 ER -