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Skeletal and cardiac muscle contractile activation: tropomyosin "rocks and rolls". Export

News Physiol Sci, Vol. 16 (April 2001), pp. 49-55.

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Changes in thin filament structure induced by Ca(2+) binding to troponin and subsequent strong cross-bridge binding regulate additional strong cross-bridge attachment, force development, and dependence of force on sarcomere length in skeletal and cardiac muscle. Variations in activation properties account for functional differences between these muscle types.


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