[Effect of tetradrine on electrophysilogic changes caused by rising of left ventricular preload in guinea pigs] Export

@article{citeulike:690813, abstract = {OBJECTIVE: To investigate the changes of guinea pig heart electrophysiological properties caused by increasing left ventricular preload, and to assess the effects of tetradrine on these changes. METHOD: Working model preparation of guinea pig hearts in vitro was used, and the preload of left ventricle was increased by adjusting the prefusion pressure of left atria. The changes of heart electrophysiologic parameters including monophasic action potential duration (MAPD90), monophasic action potential amplitude (MAPA), effective refractory period (ERP) and ventricular fibrillation threshold (VFT) were observed before and after altering the preload of left ventricle, and compared in the absence and presence of tetradrine, streptomycin or verapamil. RESULT: The rising of left ventricular preload led to shortening of MAPD90, ERP, and to descent of MAPA, VFT (all P<0.01). Both Tetradrine and streptomycin inhibited these changes of heart electrophysiologic parameters caused by elevation of left ventricular afterload (all P<0.01). In contrast, verapamil had no effects on the preload-related electrophysiological changes (all P>0.05). CONCLUSION: Electrophysiologic changes caused by increasing left ventricular preload may be inhibited by tetrandrine, through inhibition of stretch-activated ion channels.}, address = {Cardiovascular Disease Department, First Hospital Affiliated to Medical College of Zhejiang University, Hangzhou 310003, Zhejiang, China. wangxx19730312@yahoo.com.cn}, author = {Wang, X. X. and Chen, J. Z. and Cheng, L. X. and Zhou, L. L.}, citeulike-article-id = {690813}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/15615416}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=15615416}, issn = {1001-5302}, journal = {Zhongguo Zhong Yao Za Zhi}, keywords = {guinea, map, pig}, month = {November}, number = {11}, pages = {1054--1056}, posted-at = {2006-06-09 09:45:02}, priority = {5}, title = {[Effect of tetradrine on electrophysilogic changes caused by rising of left ventricular preload in guinea pigs]}, url = {http://view.ncbi.nlm.nih.gov/pubmed/15615416}, volume = {28}, year = {2003} }

TY - JOUR ID - citeulike:690813 L3 - citeulike-article-id:690813 N2 - OBJECTIVE: To investigate the changes of guinea pig heart electrophysiological properties caused by increasing left ventricular preload, and to assess the effects of tetradrine on these changes. METHOD: Working model preparation of guinea pig hearts in vitro was used, and the preload of left ventricle was increased by adjusting the prefusion pressure of left atria. The changes of heart electrophysiologic parameters including monophasic action potential duration (MAPD90), monophasic action potential amplitude (MAPA), effective refractory period (ERP) and ventricular fibrillation threshold (VFT) were observed before and after altering the preload of left ventricle, and compared in the absence and presence of tetradrine, streptomycin or verapamil. RESULT: The rising of left ventricular preload led to shortening of MAPD90, ERP, and to descent of MAPA, VFT (all P<0.01). Both Tetradrine and streptomycin inhibited these changes of heart electrophysiologic parameters caused by elevation of left ventricular afterload (all P<0.01). In contrast, verapamil had no effects on the preload-related electrophysiological changes (all P>0.05). CONCLUSION: Electrophysiologic changes caused by increasing left ventricular preload may be inhibited by tetrandrine, through inhibition of stretch-activated ion channels. IS - 11 JF - Zhongguo Zhong Yao Za Zhi SN - 1001-5302 AD - Cardiovascular Disease Department, First Hospital Affiliated to Medical College of Zhejiang University, Hangzhou 310003, Zhejiang, China. wangxx19730312@yahoo.com.cn EP - 1056 TI - [Effect of tetradrine on electrophysilogic changes caused by rising of left ventricular preload in guinea pigs] VL - 28 SP - 1054 KW - guinea KW - map KW - pig AU - Wang, XX AU - Chen, JZ AU - Cheng, LX AU - Zhou, LL PY - 2003/11// UR - http://view.ncbi.nlm.nih.gov/pubmed/15615416 ER -