Global versus local processing of frequency-modulated tones in gerbils: An animal model of lateralized auditory cortex functions Export

@article{Wetzel:2008p1884, abstract = {Hemispheric asymmetries of speech and music processing might arise from more basic specializations of left and right auditory cortex (AC). It is not clear, however, whether such asymmetries are unique to humans, i.e., consequences of speech and music, or whether comparable lateralized AC functions exist in nonhuman animals, as evolutionary precursors. Here, we investigated the cortical lateralization of perception of linearly frequency-modulated (FM) tones in gerbils, a rodent species with human-like low-frequency hearing. Using a footshock-reinforced shuttle-box avoidance go/no-go procedure in a total of 178 gerbils, we found that (i) the discrimination of direction of continuous FM (rising versus falling sweeps, 250-ms duration) was impaired by right but not left AC lesions; (ii) the discrimination of direction of segmented FM (50-ms segments, 50-ms silent gaps, total duration 250 ms) was impaired by bilateral but not unilateral AC lesions; (iii) the discrimination of gap durations (10--30 ms) in segmented FM was impaired by left but not right AC lesions. AC lesions before and after training resulted in similar effects. Together, these experiments suggest that right and left AC, even in rodents, use different strategies in analyzing FM stimuli. Thus, the right AC, by using global cues, determines the direction of continuous and segmented FM but cannot discriminate gap durations. The left AC, by using local cues, discriminates gap durations and determines FM direction only when additional segmental information is available.}, author = {Wetzel, Wolfram and Ohl, Frank and Scheich, Henning}, citeulike-article-id = {3008677}, citeulike-linkout-0 = {http://www.pnas.org/cgi/content/full/105/18/6753}, citeulike-linkout-1 = {http://dx.doi.org/10.1073/pnas.0707844105}, doi = {10.1073/pnas.0707844105}, journal = {Proceedings of the National Academy of Sciences}, keywords = {journalclub}, local-url = {file://localhost/Users/jannishildebrandt/Documents/Papers/2008/Wetzel/Proceedings\%20of\%20the\%20National\%20Academy\%20of\%20Sciences\%202008\%20Wetzel.pdf}, month = {May}, number = {18}, pages = {6753}, posted-at = {2008-07-16 15:53:07}, priority = {2}, title = {Global versus local processing of frequency-modulated tones in gerbils: An animal model of lateralized auditory cortex functions}, url = {http://dx.doi.org/10.1073/pnas.0707844105}, volume = {105}, year = {2008} }

TY - JOUR ID - Wetzel:2008p1884 L3 - citeulike-article-id:3008677 N2 - Hemispheric asymmetries of speech and music processing might arise from more basic specializations of left and right auditory cortex (AC). It is not clear, however, whether such asymmetries are unique to humans, i.e., consequences of speech and music, or whether comparable lateralized AC functions exist in nonhuman animals, as evolutionary precursors. Here, we investigated the cortical lateralization of perception of linearly frequency-modulated (FM) tones in gerbils, a rodent species with human-like low-frequency hearing. Using a footshock-reinforced shuttle-box avoidance go/no-go procedure in a total of 178 gerbils, we found that (i) the discrimination of direction of continuous FM (rising versus falling sweeps, 250-ms duration) was impaired by right but not left AC lesions; (ii) the discrimination of direction of segmented FM (50-ms segments, 50-ms silent gaps, total duration 250 ms) was impaired by bilateral but not unilateral AC lesions; (iii) the discrimination of gap durations (10--30 ms) in segmented FM was impaired by left but not right AC lesions. AC lesions before and after training resulted in similar effects. Together, these experiments suggest that right and left AC, even in rodents, use different strategies in analyzing FM stimuli. Thus, the right AC, by using global cues, determines the direction of continuous and segmented FM but cannot discriminate gap durations. The left AC, by using local cues, discriminates gap durations and determines FM direction only when additional segmental information is available. IS - 18 JF - Proceedings of the National Academy of Sciences EP - 6753 TI - Global versus local processing of frequency-modulated tones in gerbils: An animal model of lateralized auditory cortex functions VL - 105 KW - journalclub AU - Wetzel, Wolfram AU - Ohl, Frank AU - Scheich, Henning PY - 2008/May// UR - http://dx.doi.org/10.1073/pnas.0707844105 ER -