Secretory phospholipase A2 IIA is up-regulated by TNF-alpha and IL-1alpha/beta after transient focal cerebral ischemia in rat. Export

@article{adibhatla07secretory, abstract = {Cerebral ischemia initiates an inflammatory response in the brain that is associated with the induction of a variety of cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1alpha/beta (IL-1alpha/beta) that contributes to stroke injury. Transient middle cerebral artery occlusion (tMCAO) in spontaneously hypertensive rat (SHR) resulted in significant increases in TNF-alpha and IL-1beta levels. We have previously demonstrated up-regulation of secretory phospholipase A2 IIA (sPLA2 IIA) mRNA and protein expression, increased PLA2 activity, and loss of phosphatidylcholine after 1-h tMCAO and 24-h reperfusion in SHR. Treatment with TNF-alpha antibody or IL-1 receptor antagonist significantly attenuated infarction volume, sPLA2 IIA protein expression, PLA2 activity and significantly restored phosphatidylcholine levels after tMCAO. This suggests that cytokine induction up-regulates sPLA2 IIA protein expression, resulting in altered lipid metabolism that contributes to stroke injury.}, address = {Department of Neurological Surgery, University of Wisconsin, and Veterans Administration Hospital, Madison, WI 53705, USA. adibhatl@neurosurg.wisc.edu}, author = {Adibhatla, R. M. and Hatcher, J. F.}, citeulike-article-id = {1971169}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.brainres.2006.11.080}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17204250}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17204250}, day = {23}, doi = {10.1016/j.brainres.2006.11.080}, issn = {0006-8993}, journal = {Brain Res}, keywords = {a2, cyotikines, phospholipase}, month = {February}, number = {1}, pages = {199--205}, posted-at = {2007-11-24 08:55:59}, priority = {2}, title = {Secretory phospholipase A2 IIA is up-regulated by TNF-alpha and IL-1alpha/beta after transient focal cerebral ischemia in rat.}, url = {http://dx.doi.org/10.1016/j.brainres.2006.11.080}, volume = {1134}, year = {2007} }

TY - JOUR ID - adibhatla07secretory L3 - citeulike-article-id:1971169 N2 - Cerebral ischemia initiates an inflammatory response in the brain that is associated with the induction of a variety of cytokines, including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1alpha/beta (IL-1alpha/beta) that contributes to stroke injury. Transient middle cerebral artery occlusion (tMCAO) in spontaneously hypertensive rat (SHR) resulted in significant increases in TNF-alpha and IL-1beta levels. We have previously demonstrated up-regulation of secretory phospholipase A2 IIA (sPLA2 IIA) mRNA and protein expression, increased PLA2 activity, and loss of phosphatidylcholine after 1-h tMCAO and 24-h reperfusion in SHR. Treatment with TNF-alpha antibody or IL-1 receptor antagonist significantly attenuated infarction volume, sPLA2 IIA protein expression, PLA2 activity and significantly restored phosphatidylcholine levels after tMCAO. This suggests that cytokine induction up-regulates sPLA2 IIA protein expression, resulting in altered lipid metabolism that contributes to stroke injury. IS - 1 JF - Brain Res SN - 0006-8993 AD - Department of Neurological Surgery, University of Wisconsin, and Veterans Administration Hospital, Madison, WI 53705, USA. adibhatl@neurosurg.wisc.edu EP - 205 TI - Secretory phospholipase A2 IIA is up-regulated by TNF-alpha and IL-1alpha/beta after transient focal cerebral ischemia in rat. VL - 1134 SP - 199 KW - a2 KW - cyotikines KW - phospholipase AU - Adibhatla, RM AU - Hatcher, JF PY - 2007/02/23/ UR - http://dx.doi.org/10.1016/j.brainres.2006.11.080 ER -