Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling Export

@article{citeulike:1522973, abstract = {Pex5p, which is the import receptor for peroxisomal matrix proteins harboring a type I signal sequence (PTS1), is mono- and polyubiquitinated in Saccharomyces cerevisiae. We identified Pex5p as a molecular target for Pex4p-dependent monoubiquitination and demonstrated that either poly- or monoubiquitination of the receptor is required for the ATP-dependent release of the protein from the peroxisomal membrane to the cytosol as part of the receptor cycle. Therefore, the energy requirement of the peroxisomal import pathway has to be extended by a second ATP-dependent step, namely receptor monoubiquitination. 10.1083/jcb.200611012}, author = {Platta, Harald W. and Magraoui, Fouzi E. and Schlee, Daniel and Grunau, Silke and Girzalsky, Wolfgang and Erdmann, Ralf}, citeulike-article-id = {1522973}, citeulike-linkout-0 = {http://dx.doi.org/10.1083/jcb.200611012}, citeulike-linkout-1 = {http://www.jcb.org/cgi/content/abstract/177/2/197}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/17452527}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=17452527}, day = {23}, doi = {10.1083/jcb.200611012}, journal = {J. Cell Biol.}, keywords = {peroxisome, pex5p}, month = {April}, number = {2}, pages = {197--204}, posted-at = {2007-07-30 20:53:56}, priority = {2}, title = {Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling}, url = {http://dx.doi.org/10.1083/jcb.200611012}, volume = {177}, year = {2007} }

TY - JOUR ID - citeulike:1522973 L3 - citeulike-article-id:1522973 N2 - Pex5p, which is the import receptor for peroxisomal matrix proteins harboring a type I signal sequence (PTS1), is mono- and polyubiquitinated in Saccharomyces cerevisiae. We identified Pex5p as a molecular target for Pex4p-dependent monoubiquitination and demonstrated that either poly- or monoubiquitination of the receptor is required for the ATP-dependent release of the protein from the peroxisomal membrane to the cytosol as part of the receptor cycle. Therefore, the energy requirement of the peroxisomal import pathway has to be extended by a second ATP-dependent step, namely receptor monoubiquitination. 10.1083/jcb.200611012 IS - 2 JF - J. Cell Biol. EP - 204 TI - Ubiquitination of the peroxisomal import receptor Pex5p is required for its recycling VL - 177 SP - 197 KW - peroxisome KW - pex5p AU - Platta, Harald AU - Magraoui, Fouzi AU - Schlee, Daniel AU - Grunau, Silke AU - Girzalsky, Wolfgang AU - Erdmann, Ralf PY - 2007/04/23/ UR - http://dx.doi.org/10.1083/jcb.200611012 ER -