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Molecular Modeling Studies of ABC Transporters Involved in Multidrug Resistance. Export

Mini reviews in medicinal chemistry, Vol. 9, No. 2. (February 2009), pp. 186-193.

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abc_transporter computational mdr

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Multidrug resistance (MDR) is a limitation to cancer chemotherapy, antibiotic treatment and HIV medication. Molecular models of the ABC transporters ABCB1 (P-glycoprotein), ABCC4 (multidrug resistance protein 4 (MRP4)) and ABCC5 (MRP5), which are involved in MDR, may aid in the development of drugs inhibiting anticancer agents efflux.


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