A systems perspective on the effective connectivity of overt speech production. Export

@article{citeulike:4481974, abstract = {The aim of this study was to provide a computational system model of effective connectivity in the human brain underlying overt speech production. Meta-analysis of neuroimaging studies and functional magnetic resonance imaging data acquired during a verbal fluency task revealed a core network consisting of Brodmann's area (BA) 44 in Broca's region, anterior insula, basal ganglia, cerebellum, premotor cortex (PMC, BA 6) and primary motor cortex (M1, areas 4a/4p). Dynamic causal modelling (DCM) indicated the highest evidence for a system architecture featuring the insula in a serial position between BA 44 and two parallel nodes (cerebellum/basal ganglia), from which information converges onto the PMC and finally M1. Parameter inference revealed that effective connectivity from the insular relay into the cerebellum/basal ganglia is primarily task driven (preparation) while the output into the cortical motor system strongly depends on the actual word production rate (execution). DCM hence allowed not only a quantitative characterization of the human speech production network, but also the distinction of a preparatory and an executive subsystem within it. The proposed model of physiological integration during speech production may now serve as a reference for investigations into the neurobiology of pathological states such as dysarthria and apraxia of speech.}, author = {Eickhoff, Simon B. and Heim, Stefan and Zilles, Karl and Amunts, Katrin}, citeulike-article-id = {4481974}, citeulike-linkout-0 = {http://dx.doi.org/10.1098/rsta.2008.0287}, citeulike-linkout-1 = {http://rsta.royalsocietypublishing.org/content/367/1896/2399?rss=1.abstract}, citeulike-linkout-2 = {http://rsta.royalsocietypublishing.org/content/367/1896/2399?rss=1.full.pdf}, citeulike-linkout-3 = {http://view.ncbi.nlm.nih.gov/pubmed/19414462}, citeulike-linkout-4 = {http://www.hubmed.org/display.cgi?uids=19414462}, day = {13}, doi = {10.1098/rsta.2008.0287}, issn = {1364-503X}, journal = {Philosophical transactions. Series A, Mathematical, physical, and engineering sciences}, keywords = {connectivity, fmri, ideas, leipzig09bcit}, month = {June}, number = {1896}, pages = {2399--2421}, posted-at = {2009-08-25 08:53:08}, priority = {2}, title = {A systems perspective on the effective connectivity of overt speech production.}, url = {http://dx.doi.org/10.1098/rsta.2008.0287}, volume = {367}, year = {2009} }

TY - JOUR ID - citeulike:4481974 L3 - citeulike-article-id:4481974 N2 - The aim of this study was to provide a computational system model of effective connectivity in the human brain underlying overt speech production. Meta-analysis of neuroimaging studies and functional magnetic resonance imaging data acquired during a verbal fluency task revealed a core network consisting of Brodmann's area (BA) 44 in Broca's region, anterior insula, basal ganglia, cerebellum, premotor cortex (PMC, BA 6) and primary motor cortex (M1, areas 4a/4p). Dynamic causal modelling (DCM) indicated the highest evidence for a system architecture featuring the insula in a serial position between BA 44 and two parallel nodes (cerebellum/basal ganglia), from which information converges onto the PMC and finally M1. Parameter inference revealed that effective connectivity from the insular relay into the cerebellum/basal ganglia is primarily task driven (preparation) while the output into the cortical motor system strongly depends on the actual word production rate (execution). DCM hence allowed not only a quantitative characterization of the human speech production network, but also the distinction of a preparatory and an executive subsystem within it. The proposed model of physiological integration during speech production may now serve as a reference for investigations into the neurobiology of pathological states such as dysarthria and apraxia of speech. IS - 1896 JF - Philosophical transactions. Series A, Mathematical, physical, and engineering sciences SN - 1364-503X EP - 2421 TI - A systems perspective on the effective connectivity of overt speech production. VL - 367 SP - 2399 KW - connectivity KW - fmri KW - ideas KW - leipzig09bcit AU - Eickhoff, Simon AU - Heim, Stefan AU - Zilles, Karl AU - Amunts, Katrin PY - 2009/06/13/ UR - http://dx.doi.org/10.1098/rsta.2008.0287 ER -