International Society of Geriatric Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency. Export

@article{citeulike:2087258, abstract = {A SIOG taskforce was formed to discuss best clinical practice for elderly cancer patients with renal insufficiency. This manuscript outlines recommended dosing adjustments for cancer drugs in this population according to renal function. Dosing adjustments have been made for drugs in current use which have recommendations in renal insufficiency and the elderly, focusing on drugs which are renally eliminated or are known to be nephrotoxic. Recommendations are based on pharmacokinetic and/or pharmacodynamic data where available. The taskforce recommend that before initiating therapy, some form of geriatric assessment should be conducted that includes evaluation of comorbidities and polypharmacy, hydration status and renal function (using available formulae). Within each drug class, it is sensible to use agents which are less likely to be influenced by renal clearance. Pharmacokinetic and pharmacodynamic data of anticancer agents in the elderly are needed in order to maximise efficacy whilst avoiding unacceptable toxicity.}, address = {Memorial Sloan-Kettering Cancer Centre, New York, USA.}, author = {Lichtman, S. M. and Wildiers, H. and Launay-Vacher, V. and Steer, C. and Chatelut, E. and Aapro, M.}, citeulike-article-id = {2087258}, citeulike-linkout-0 = {http://dx.doi.org/10.1016/j.ejca.2006.11.004}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/17222747}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=17222747}, doi = {10.1016/j.ejca.2006.11.004}, issn = {0959-8049}, journal = {Eur J Cancer}, keywords = {cancer, ckd, geriatric, insufficiency, launay-vacher, oncology, renal}, month = {January}, number = {1}, pages = {14--34}, posted-at = {2007-12-11 00:15:32}, priority = {0}, title = {International Society of Geriatric Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency.}, url = {http://dx.doi.org/10.1016/j.ejca.2006.11.004}, volume = {43}, year = {2007} }

TY - JOUR ID - citeulike:2087258 L3 - citeulike-article-id:2087258 N2 - A SIOG taskforce was formed to discuss best clinical practice for elderly cancer patients with renal insufficiency. This manuscript outlines recommended dosing adjustments for cancer drugs in this population according to renal function. Dosing adjustments have been made for drugs in current use which have recommendations in renal insufficiency and the elderly, focusing on drugs which are renally eliminated or are known to be nephrotoxic. Recommendations are based on pharmacokinetic and/or pharmacodynamic data where available. The taskforce recommend that before initiating therapy, some form of geriatric assessment should be conducted that includes evaluation of comorbidities and polypharmacy, hydration status and renal function (using available formulae). Within each drug class, it is sensible to use agents which are less likely to be influenced by renal clearance. Pharmacokinetic and pharmacodynamic data of anticancer agents in the elderly are needed in order to maximise efficacy whilst avoiding unacceptable toxicity. IS - 1 JF - Eur J Cancer SN - 0959-8049 AD - Memorial Sloan-Kettering Cancer Centre, New York, USA. EP - 34 TI - International Society of Geriatric Oncology (SIOG) recommendations for the adjustment of dosing in elderly cancer patients with renal insufficiency. VL - 43 SP - 14 KW - cancer KW - ckd KW - geriatric KW - insufficiency KW - launay-vacher KW - oncology KW - renal AU - Lichtman, SM AU - Wildiers, H AU - Launay-Vacher, V AU - Steer, C AU - Chatelut, E AU - Aapro, M PY - 2007/01// UR - http://dx.doi.org/10.1016/j.ejca.2006.11.004 ER -