Prevalence of renal insufficiency in breast cancer patients and related pharmacological issues. Export

@article{citeulike:3224488, abstract = {The Renal Insufficiency and Anticancer Medications (IRMA) study is a French national, observational study which demonstrated the high prevalence of abnormal renal function in a population of 4,684 solid tumour patients. Among them, 50-60\% had decreased renal function defined as CrCl below 90 and 80\% were treated with anticancer drugs that either necessitated dosage adjustment in case of RI or were potentially nephrotoxic drugs. Since patients and drugs used differ depending on the type of tumour, the IRMA Study Group started analyses in different subgroups of patients. In the 1898 IRMA patients with breast cancer, the prevalence of RI was still very high in spite of a normal serum creatinine in almost all cases. Some anticancer drugs, as in particular some bisphosphonates, capecitabine and platinum salts, may be nephrotoxic and/or need dosage adjustment. However other important drugs in breast cancer do not require dose reduction, and do not present with potential nephrotoxicity (anthracyclines, taxanes, trastuzumab). Both issues seem to be slightly but significantly more important in patients with bone metastases as compared to patients with a non-metastatic disease.}, address = {Department of Nephrology, H\^{o}pital Piti\'{e}-Salp\^{e}tri\`{e}re, 47-83 Boulevard de l'H\^{o}pital, 75013, Paris, France, vincent.launay-vacher@psl.aphp.fr.}, author = {Launay-Vacher, Vincent and Gligorov, Joseph and Le Tourneau, Christophe and Janus, Nicolas and Spano, Jean-Philippe P. and Ray-Coquard, Isabelle and Oudard, St\'{e}phane and Pourrat, Xavier and Morere, Jean-Fran\c{c}ois F. and Deray, Gilbert and Beuzeboc, Philippe and {}}, citeulike-article-id = {3224488}, citeulike-linkout-0 = {http://dx.doi.org/10.1007/s10549-008-0131-1}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18704681}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18704681}, day = {15}, doi = {10.1007/s10549-008-0131-1}, issn = {0167-6806}, journal = {Breast cancer research and treatment}, keywords = {cancer, insufficiecy, irma, renal}, month = {August}, posted-at = {2008-09-11 07:07:07}, priority = {5}, title = {Prevalence of renal insufficiency in breast cancer patients and related pharmacological issues.}, url = {http://dx.doi.org/10.1007/s10549-008-0131-1}, year = {2008} }

TY - JOUR ID - citeulike:3224488 L3 - citeulike-article-id:3224488 N2 - The Renal Insufficiency and Anticancer Medications (IRMA) study is a French national, observational study which demonstrated the high prevalence of abnormal renal function in a population of 4,684 solid tumour patients. Among them, 50-60% had decreased renal function defined as CrCl below 90 and 80% were treated with anticancer drugs that either necessitated dosage adjustment in case of RI or were potentially nephrotoxic drugs. Since patients and drugs used differ depending on the type of tumour, the IRMA Study Group started analyses in different subgroups of patients. In the 1898 IRMA patients with breast cancer, the prevalence of RI was still very high in spite of a normal serum creatinine in almost all cases. Some anticancer drugs, as in particular some bisphosphonates, capecitabine and platinum salts, may be nephrotoxic and/or need dosage adjustment. However other important drugs in breast cancer do not require dose reduction, and do not present with potential nephrotoxicity (anthracyclines, taxanes, trastuzumab). Both issues seem to be slightly but significantly more important in patients with bone metastases as compared to patients with a non-metastatic disease. JF - Breast cancer research and treatment SN - 0167-6806 AD - Department of Nephrology, Hôpital Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013, Paris, France, vincent.launay-vacher@psl.aphp.fr. TI - Prevalence of renal insufficiency in breast cancer patients and related pharmacological issues. KW - cancer KW - insufficiecy KW - irma KW - renal AU - Launay-Vacher, Vincent AU - Gligorov, Joseph AU - Le Tourneau, Christophe AU - Janus, Nicolas AU - Spano, Jean-Philippe AU - Ray-Coquard, Isabelle AU - Oudard, Stéphane AU - Pourrat, Xavier AU - Morere, Jean-François AU - Deray, Gilbert AU - Beuzeboc, Philippe PY - 2008/08/15/ UR - http://dx.doi.org/10.1007/s10549-008-0131-1 ER -