Activity of antibiotics against Fusarium and Aspergillus Export

@article{citeulike:4299556, abstract = {Background/aimsTo study the susceptibility of Fusarium and Aspergillus isolated from keratitis to amoxicillin, cefazolin, chloramphenicol, moxifloxacin, tobramycin and benzalkonium chloride (BAK). Methods10 isolates of Fusarium and 10 isolates of Aspergillus from cases of fungal keratitis at Aravind Eye Hospital in South India were tested using microbroth dilution for susceptibility to amoxicillin, cefazolin, chloramphenicol, moxifloxacin, tobramycin and BAK. The minimum inhibitory concentration (MIC) median and 90th percentile were determined. ResultsBAK had the lowest MIC for both Fusarium and Aspergillus. Chloramphenicol had activity against both Fusarium and Aspergillus, while moxifloxacin and tobramycin had activity against Fusarium but not Aspergillus. ConclusionsThe susceptibility of Fusarium to tobramycin, moxifloxacin, chloramphenicol and BAK and of Aspergillus to chloramphenicol and BAK may explain anecdotal reports of fungal ulcers that improved with antibiotic treatment alone. While some of the MICs of antibiotics and BAK are lower than the typically prescribed concentrations, they are not in the range of antifungal agents such as voriconazole, natamycin and amphotericin B. Antibiotics may, however, have a modest effect on Fusarium and Aspergillus when used as initial treatment prior to identification of the pathological organism. 10.1136/bjo.2008.142364}, author = {Day, S. and Lalitha, P. and Haug, S. and Fothergill, A. W. and Cevallos, V. and Vijayakumar, R. and Prajna, N. V. and Acharya, N. R. and Mcleod, S. D. and Lietman, T. M.}, citeulike-article-id = {4299556}, citeulike-linkout-0 = {http://dx.doi.org/10.1136/bjo.2008.142364}, citeulike-linkout-1 = {http://bjo.bmj.com/cgi/content/abstract/93/1/116}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18952649}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18952649}, day = {1}, doi = {10.1136/bjo.2008.142364}, journal = {Br J Ophthalmol}, month = {January}, number = {1}, pages = {116--119}, posted-at = {2009-04-11 09:14:51}, priority = {2}, title = {Activity of antibiotics against Fusarium and Aspergillus}, url = {http://dx.doi.org/10.1136/bjo.2008.142364}, volume = {93}, year = {2009} }

TY - JOUR ID - citeulike:4299556 L3 - citeulike-article-id:4299556 N2 - Background/aimsTo study the susceptibility of Fusarium and Aspergillus isolated from keratitis to amoxicillin, cefazolin, chloramphenicol, moxifloxacin, tobramycin and benzalkonium chloride (BAK). Methods10 isolates of Fusarium and 10 isolates of Aspergillus from cases of fungal keratitis at Aravind Eye Hospital in South India were tested using microbroth dilution for susceptibility to amoxicillin, cefazolin, chloramphenicol, moxifloxacin, tobramycin and BAK. The minimum inhibitory concentration (MIC) median and 90th percentile were determined. ResultsBAK had the lowest MIC for both Fusarium and Aspergillus. Chloramphenicol had activity against both Fusarium and Aspergillus, while moxifloxacin and tobramycin had activity against Fusarium but not Aspergillus. ConclusionsThe susceptibility of Fusarium to tobramycin, moxifloxacin, chloramphenicol and BAK and of Aspergillus to chloramphenicol and BAK may explain anecdotal reports of fungal ulcers that improved with antibiotic treatment alone. While some of the MICs of antibiotics and BAK are lower than the typically prescribed concentrations, they are not in the range of antifungal agents such as voriconazole, natamycin and amphotericin B. Antibiotics may, however, have a modest effect on Fusarium and Aspergillus when used as initial treatment prior to identification of the pathological organism. 10.1136/bjo.2008.142364 IS - 1 JF - Br J Ophthalmol EP - 119 TI - Activity of antibiotics against Fusarium and Aspergillus VL - 93 SP - 116 AU - Day, S AU - Lalitha, P AU - Haug, S AU - Fothergill, AW AU - Cevallos, V AU - Vijayakumar, R AU - Prajna, NV AU - Acharya, NR AU - Mcleod, SD AU - Lietman, TM PY - 2009/01/01/ UR - http://dx.doi.org/10.1136/bjo.2008.142364 ER -