Revisiting Crohn's disease as a primary immunodeficiency of macrophages Export

@article{citeulike:5801920, abstract = {Despite two decades of mouse immunology and human genetics studies, the pathogenesis of Crohn's disease (CD) remains elusive. New clinical investigations suggest that CD may be caused by inborn errors of macrophages. These errors may result in impaired attraction of granulocytes to the gut wall, causing impaired clearance of intruding bacteria, thereby precipitating the formation of granulomas. This theory paves the way for a macrophage-based Mendelian genetic dissection of CD. 10.1084/jem.20091683}, author = {Casanova, Jean-Laurent and Abel, Laurent}, citeulike-article-id = {5801920}, citeulike-linkout-0 = {http://dx.doi.org/10.1084/jem.20091683}, citeulike-linkout-1 = {http://jem.rupress.org/cgi/content/abstract/206/9/1839}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19687225}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19687225}, day = {31}, doi = {10.1084/jem.20091683}, journal = {J. Exp. Med.}, keywords = {crohn, imid, immunodeficiency, keyser, macrophage}, month = {August}, number = {9}, pages = {1839--1843}, posted-at = {2009-09-18 10:42:02}, priority = {0}, title = {Revisiting Crohn's disease as a primary immunodeficiency of macrophages}, url = {http://dx.doi.org/10.1084/jem.20091683}, volume = {206}, year = {2009} }

TY - JOUR ID - citeulike:5801920 L3 - citeulike-article-id:5801920 N2 - Despite two decades of mouse immunology and human genetics studies, the pathogenesis of Crohn's disease (CD) remains elusive. New clinical investigations suggest that CD may be caused by inborn errors of macrophages. These errors may result in impaired attraction of granulocytes to the gut wall, causing impaired clearance of intruding bacteria, thereby precipitating the formation of granulomas. This theory paves the way for a macrophage-based Mendelian genetic dissection of CD. 10.1084/jem.20091683 IS - 9 JF - J. Exp. Med. EP - 1843 TI - Revisiting Crohn's disease as a primary immunodeficiency of macrophages VL - 206 SP - 1839 KW - crohn KW - imid KW - immunodeficiency KW - keyser KW - macrophage AU - Casanova, Jean-Laurent AU - Abel, Laurent PY - 2009/08/31/ UR - http://dx.doi.org/10.1084/jem.20091683 ER -