A high-resolution recombination map of the human genome Export

@article{Kong_et_al02, abstract = {Determination of recombination rates across the human genome has been constrained by the limited resolution and accuracy of existing genetic maps and the draft genome sequence. We have genotyped 5,136 microsatellite markers for 146 families, with a total of 1,257 meiotic events, to build a high-resolution genetic map meant to: (i) improve the genetic order of polymorphic markers; (ii) improve the precision of estimates of genetic distances; (iii) correct portions of the sequence assembly and SNP map of the human genome; and (iv) build a map of recombination rates. Recombination rates are significantly correlated with both cytogenetic structures (staining intensity of G bands) and sequence (GC content, CpG motifs and poly(A)/poly(T) stretches). Maternal and paternal chromosomes show many differences in locations of recombination maxima. We detected systematic differences in recombination rates between mothers and between gametes from the same mother, suggesting that there is some underlying component determined by both genetic and environmental factors that affects maternal recombination rates.}, address = {deCODE genetics, Sturlugotu 8, IS-101 Reykjavik, Iceland. kong@decode.is}, author = {Kong, A. and Gudbjartsson, D. F. and Sainz, J. and Jonsdottir, G. M. and Gudjonsson, S. A. and Richardsson, B. and Sigurdardottir, S. and Barnard, J. and Hallbeck, B. and Masson, G. and Shlien, A. and Palsson, S. T. and Frigge, M. L. and Thorgeirsson, T. E. and Gulcher, J. R. and Stefansson, K.}, citeulike-article-id = {214013}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/ng917}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/ng917}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/12053178}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=12053178}, day = {10}, doi = {10.1038/ng917}, issn = {1061-4036}, journal = {Nature Genetics}, keywords = {ld}, month = {June}, number = {3}, pages = {241--247}, posted-at = {2006-12-13 14:50:40}, priority = {2}, publisher = {Nature Publishing Group}, title = {A high-resolution recombination map of the human genome}, url = {http://dx.doi.org/10.1038/ng917}, volume = {31}, year = {2002} }

TY - JOUR ID - Kong_et_al02 L3 - citeulike-article-id:214013 N2 - Determination of recombination rates across the human genome has been constrained by the limited resolution and accuracy of existing genetic maps and the draft genome sequence. We have genotyped 5,136 microsatellite markers for 146 families, with a total of 1,257 meiotic events, to build a high-resolution genetic map meant to: (i) improve the genetic order of polymorphic markers; (ii) improve the precision of estimates of genetic distances; (iii) correct portions of the sequence assembly and SNP map of the human genome; and (iv) build a map of recombination rates. Recombination rates are significantly correlated with both cytogenetic structures (staining intensity of G bands) and sequence (GC content, CpG motifs and poly(A)/poly(T) stretches). Maternal and paternal chromosomes show many differences in locations of recombination maxima. We detected systematic differences in recombination rates between mothers and between gametes from the same mother, suggesting that there is some underlying component determined by both genetic and environmental factors that affects maternal recombination rates. IS - 3 JF - Nature Genetics SN - 1061-4036 AD - deCODE genetics, Sturlugotu 8, IS-101 Reykjavik, Iceland. kong@decode.is EP - 247 TI - A high-resolution recombination map of the human genome PB - Nature Publishing Group VL - 31 SP - 241 KW - ld AU - Kong, A AU - Gudbjartsson, DF AU - Sainz, J AU - Jonsdottir, GM AU - Gudjonsson, SA AU - Richardsson, B AU - Sigurdardottir, S AU - Barnard, J AU - Hallbeck, B AU - Masson, G AU - Shlien, A AU - Palsson, ST AU - Frigge, ML AU - Thorgeirsson, TE AU - Gulcher, JR AU - Stefansson, K PY - 2002/06/10/ UR - http://dx.doi.org/10.1038/ng917 ER -