Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes. Export

@article{Honeyman_et_al00, abstract = {Pancreatic islet autoimmunity leading to type 1 diabetes could be triggered by viruses in genetically susceptible individuals. Rotavirus (RV), the most common cause of childhood gastroenteritis, contains peptide sequences highly similar to T-cell epitopes in the islet autoantigens GAD and tyrosine phosphatase IA-2 (IA-2), suggesting T-cells to RV could trigger islet autoimmunity by molecular mimicry. We therefore sought an association between RV infection and islet autoantibody markers in children at risk for diabetes who were followed from birth. There was a specific and highly significant association between RV seroconversion and increases in any of these antibodies: 86\% of antibodies to IA-2, 62\% to insulin, and 50\% to GAD first appeared or increased with increases in RV IgG or IgA. RV infection may therefore trigger or exacerbate islet autoimmunity in genetically susceptible children.}, address = {Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia. honeyman@wehi.edu.au}, author = {Honeyman, M. C. and Coulson, B. S. and Stone, N. L. and Gellert, S. A. and Goldwater, P. N. and Steele, C. E. and Couper, J. J. and Tait, B. D. and Colman, P. G. and Harrison, L. C.}, citeulike-article-id = {3335157}, citeulike-linkout-0 = {http://view.ncbi.nlm.nih.gov/pubmed/10923632}, citeulike-linkout-1 = {http://www.hubmed.org/display.cgi?uids=10923632}, issn = {0012-1797}, journal = {Diabetes}, keywords = {autoantibody, gad, ia2, t1d}, month = {August}, number = {8}, pages = {1319--1324}, posted-at = {2008-09-25 10:28:39}, priority = {2}, title = {Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes.}, url = {http://view.ncbi.nlm.nih.gov/pubmed/10923632}, volume = {49}, year = {2000} }

TY - JOUR ID - Honeyman_et_al00 L3 - citeulike-article-id:3335157 N2 - Pancreatic islet autoimmunity leading to type 1 diabetes could be triggered by viruses in genetically susceptible individuals. Rotavirus (RV), the most common cause of childhood gastroenteritis, contains peptide sequences highly similar to T-cell epitopes in the islet autoantigens GAD and tyrosine phosphatase IA-2 (IA-2), suggesting T-cells to RV could trigger islet autoimmunity by molecular mimicry. We therefore sought an association between RV infection and islet autoantibody markers in children at risk for diabetes who were followed from birth. There was a specific and highly significant association between RV seroconversion and increases in any of these antibodies: 86% of antibodies to IA-2, 62% to insulin, and 50% to GAD first appeared or increased with increases in RV IgG or IgA. RV infection may therefore trigger or exacerbate islet autoimmunity in genetically susceptible children. IS - 8 JF - Diabetes SN - 0012-1797 AD - Autoimmunity and Transplantation Division, Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia. honeyman@wehi.edu.au EP - 1324 TI - Association between rotavirus infection and pancreatic islet autoimmunity in children at risk of developing type 1 diabetes. VL - 49 SP - 1319 KW - autoantibody KW - gad KW - ia2 KW - t1d AU - Honeyman, MC AU - Coulson, BS AU - Stone, NL AU - Gellert, SA AU - Goldwater, PN AU - Steele, CE AU - Couper, JJ AU - Tait, BD AU - Colman, PG AU - Harrison, LC PY - 2000/08// UR - http://view.ncbi.nlm.nih.gov/pubmed/10923632 ER -