Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women. Export

@article{Pare_et_al08, abstract = {While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women's Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level (P<5x10(-8)), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P = 5.1x10(-29)) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes.}, author = {Par\'{e}, G. and Chasman, D. I. and Kellogg, M. and Zee, R. Y. and Rifai, N. and Badola, S. and Miletich, J. P. and Ridker, P. M.}, citeulike-article-id = {3444569}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pgen.1000118}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/18604267}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=18604267}, doi = {10.1371/journal.pgen.1000118}, issn = {1553-7404}, journal = {PLoS genetics}, keywords = {abo, autoimmunity, icam}, month = {July}, number = {7}, posted-at = {2008-10-23 23:22:44}, priority = {2}, title = {Novel association of {ABO} histo-blood group antigen with soluble {ICAM-1}: results of a genome-wide association study of 6,578 women.}, url = {http://dx.doi.org/10.1371/journal.pgen.1000118}, volume = {4}, year = {2008} }

TY - JOUR ID - Pare_et_al08 L3 - citeulike-article-id:3444569 N2 - While circulating levels of soluble Intercellular Adhesion Molecule 1 (sICAM-1) have been associated with diverse conditions including myocardial infarction, stroke, malaria, and diabetes, comprehensive analysis of the common genetic determinants of sICAM-1 is not available. In a genome-wide association study conducted among 6,578 participants in the Women's Genome Health Study, we find that three SNPs at the ICAM1 (19p13.2) locus (rs1799969, rs5498 and rs281437) are non-redundantly associated with plasma sICAM-1 concentrations at a genome-wide significance level (P<5x10(-8)), thus extending prior results from linkage and candidate gene studies. We also find that a single SNP (rs507666, P = 5.1x10(-29)) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations. The novel association at the ABO locus provides evidence for a previously unknown regulatory role of histo-blood group antigens in inflammatory adhesion processes. IS - 7 JF - PLoS genetics SN - 1553-7404 TI - Novel association of {ABO} histo-blood group antigen with soluble {ICAM-1}: results of a genome-wide association study of 6,578 women. VL - 4 KW - abo KW - autoimmunity KW - icam AU - Paré, G AU - Chasman, DI AU - Kellogg, M AU - Zee, RY AU - Rifai, N AU - Badola, S AU - Miletich, JP AU - Ridker, PM PY - 2008/07// UR - http://dx.doi.org/10.1371/journal.pgen.1000118 ER -