Genotype imputation. Export

@article{citeulike:5804402, abstract = {Genotype imputation is now an essential tool in the analysis of genome-wide association scans. This technique allows geneticists to accurately evaluate the evidence for association at genetic markers that are not directly genotyped. Genotype imputation is particularly useful for combining results across studies that rely on different genotyping platforms but also increases the power of individual scans. Here, we review the history and theoretical underpinnings of the technique. To illustrate performance of the approach, we summarize results from several gene mapping studies. Finally, we preview the role of genotype imputation in an era when whole genome resequencing is becoming increasingly common.}, author = {Li, Yun and Willer, Cristen and Sanna, Serena and Abecasis, Gon\c{c}alo}, citeulike-article-id = {5804402}, citeulike-linkout-0 = {http://arjournals.annualreviews.org/doi/abs/10.1146/annurev.genom.9.081307.164242}, citeulike-linkout-1 = {http://dx.doi.org/10.1146/annurev.genom.9.081307.164242}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/19715440}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=19715440}, doi = {10.1146/annurev.genom.9.081307.164242}, issn = {1545-293X}, journal = {Annual review of genomics and human genetics}, keywords = {genotyping, imputation}, number = {1}, pages = {387--406}, posted-at = {2009-11-12 18:35:25}, priority = {2}, title = {Genotype imputation.}, url = {http://dx.doi.org/10.1146/annurev.genom.9.081307.164242}, volume = {10}, year = {2009} }

TY - JOUR ID - citeulike:5804402 L3 - citeulike-article-id:5804402 N2 - Genotype imputation is now an essential tool in the analysis of genome-wide association scans. This technique allows geneticists to accurately evaluate the evidence for association at genetic markers that are not directly genotyped. Genotype imputation is particularly useful for combining results across studies that rely on different genotyping platforms but also increases the power of individual scans. Here, we review the history and theoretical underpinnings of the technique. To illustrate performance of the approach, we summarize results from several gene mapping studies. Finally, we preview the role of genotype imputation in an era when whole genome resequencing is becoming increasingly common. IS - 1 JF - Annual review of genomics and human genetics SN - 1545-293X EP - 406 TI - Genotype imputation. VL - 10 SP - 387 KW - genotyping KW - imputation AU - Li, Yun AU - Willer, Cristen AU - Sanna, Serena AU - Abecasis, Gonçalo PY - 2009/// UR - http://dx.doi.org/10.1146/annurev.genom.9.081307.164242 ER -