Allele Frequency Matching Between SNPs Reveals an Excess of Linkage Disequilibrium in Genic Regions of the Human Genome Export

@article{citeulike:890501, abstract = {Significant interest has emerged in mapping genetic susceptibility for complex traits through whole-genome association studies. These studies rely on the extent of association, i.e., linkage disequilibrium (LD), between single nucleotide polymorphisms (SNPs) across the human genome. LD describes the nonrandom association between SNP pairs and can be used as a metric when designing maximally informative panels of SNPs for association studies in human populations. Using data from the 1.58 million SNPs genotyped by Perlegen, we explored the allele frequency dependence of the LD statistic r2 both empirically and theoretically. We show that average r2 values between SNPs unmatched for allele frequency are always limited to much less than 1 (theoretical approximately 0.46 to 0.57 for this dataset). Frequency matching of SNP pairs provides a more sensitive measure for assessing the average decay of LD and generates average r2 values across nearly the entire informative range (from 0 to 0.89 through 0.95). Additionally, we analyzed the extent of perfect LD (r2 \&\#61; 1.0) using frequency-matched SNPs and found significant differences in the extent of LD in genic regions versus intergenic regions. The SNP pairs exhibiting perfect LD showed a significant bias for derived, nonancestral alleles, providing evidence for positive natural selection in the human genome.}, author = {Eberle, Michael A. and Rieder, Mark J. and Kruglyak, Leonid and Nickerson, Deborah A.}, citeulike-article-id = {890501}, citeulike-linkout-0 = {http://dx.doi.org/10.1371/journal.pgen.0020142}, citeulike-linkout-1 = {http://view.ncbi.nlm.nih.gov/pubmed/16965180}, citeulike-linkout-2 = {http://www.hubmed.org/display.cgi?uids=16965180}, doi = {10.1371/journal.pgen.0020142}, journal = {PLoS Genetics}, keywords = {ld}, month = {September}, number = {9}, pages = {e142+}, posted-at = {2006-10-10 00:00:34}, priority = {2}, title = {Allele Frequency Matching Between SNPs Reveals an Excess of Linkage Disequilibrium in Genic Regions of the Human Genome}, url = {http://dx.doi.org/10.1371/journal.pgen.0020142}, volume = {2}, year = {2006} }

TY - JOUR ID - citeulike:890501 L3 - citeulike-article-id:890501 N2 - Significant interest has emerged in mapping genetic susceptibility for complex traits through whole-genome association studies. These studies rely on the extent of association, i.e., linkage disequilibrium (LD), between single nucleotide polymorphisms (SNPs) across the human genome. LD describes the nonrandom association between SNP pairs and can be used as a metric when designing maximally informative panels of SNPs for association studies in human populations. Using data from the 1.58 million SNPs genotyped by Perlegen, we explored the allele frequency dependence of the LD statistic r2 both empirically and theoretically. We show that average r2 values between SNPs unmatched for allele frequency are always limited to much less than 1 (theoretical approximately 0.46 to 0.57 for this dataset). Frequency matching of SNP pairs provides a more sensitive measure for assessing the average decay of LD and generates average r2 values across nearly the entire informative range (from 0 to 0.89 through 0.95). Additionally, we analyzed the extent of perfect LD (r2 = 1.0) using frequency-matched SNPs and found significant differences in the extent of LD in genic regions versus intergenic regions. The SNP pairs exhibiting perfect LD showed a significant bias for derived, nonancestral alleles, providing evidence for positive natural selection in the human genome. IS - 9 JF - PLoS Genetics TI - Allele Frequency Matching Between SNPs Reveals an Excess of Linkage Disequilibrium in Genic Regions of the Human Genome VL - 2 SP - e142 KW - ld AU - Eberle, Michael AU - Rieder, Mark AU - Kruglyak, Leonid AU - Nickerson, Deborah PY - 2006/09/01/ UR - http://dx.doi.org/10.1371/journal.pgen.0020142 ER -