Copy-number variations associated with neuropsychiatric conditions. Export

@article{citeulike:3416764, abstract = {Neuropsychiatric conditions such as autism and schizophrenia have long been attributed to genetic alterations, but identifying the genes responsible has proved challenging. Microarray experiments have now revealed abundant copy-number variation--a type of variation in which stretches of DNA are duplicated, deleted and sometimes rearranged--in the human population. Genes affected by copy-number variation are good candidates for research into disease susceptibility. The complexity of neuropsychiatric genetics, however, dictates that assessment of the biomedical relevance of copy-number variants and the genes that they affect needs to be considered in an integrated context.}, author = {Cook, Edwin H. and Scherer, Stephen W.}, citeulike-article-id = {3416764}, citeulike-linkout-0 = {http://dx.doi.org/10.1038/nature07458}, citeulike-linkout-1 = {http://dx.doi.org/10.1038/nature07458}, citeulike-linkout-2 = {http://view.ncbi.nlm.nih.gov/pubmed/18923514}, citeulike-linkout-3 = {http://www.hubmed.org/display.cgi?uids=18923514}, day = {16}, doi = {10.1038/nature07458}, issn = {1476-4687}, journal = {Nature}, keywords = {autism, cnv, microarray, neuropsychiatric, review, schizophrenia}, month = {October}, number = {7215}, pages = {919--923}, posted-at = {2008-10-17 14:05:37}, priority = {2}, publisher = {Nature Publishing Group}, title = {Copy-number variations associated with neuropsychiatric conditions.}, url = {http://dx.doi.org/10.1038/nature07458}, volume = {455}, year = {2008} }

TY - JOUR ID - citeulike:3416764 L3 - citeulike-article-id:3416764 N2 - Neuropsychiatric conditions such as autism and schizophrenia have long been attributed to genetic alterations, but identifying the genes responsible has proved challenging. Microarray experiments have now revealed abundant copy-number variation--a type of variation in which stretches of DNA are duplicated, deleted and sometimes rearranged--in the human population. Genes affected by copy-number variation are good candidates for research into disease susceptibility. The complexity of neuropsychiatric genetics, however, dictates that assessment of the biomedical relevance of copy-number variants and the genes that they affect needs to be considered in an integrated context. IS - 7215 JF - Nature SN - 1476-4687 EP - 923 TI - Copy-number variations associated with neuropsychiatric conditions. PB - Nature Publishing Group VL - 455 SP - 919 KW - autism KW - cnv KW - microarray KW - neuropsychiatric KW - review KW - schizophrenia AU - Cook, Edwin AU - Scherer, Stephen PY - 2008/10/16/ UR - http://dx.doi.org/10.1038/nature07458 ER -