Point and Interval Estimation of Primary and Secondary Parameters in a Two-Stage Adaptive Clinical Trial Export

@article{citeulike:2534884, abstract = {Investigated in this paper is the point estimation and confidence intervals of the treatment efficacy parameter and related secondary parameters in a two-stage adaptive trial. Based on the minimal sufficient statistics, several alternative estimators to the sample averages are proposed to reduce the bias and to improve the precision of estimation. Confidence intervals are constructed using Woodroofe's pivot method. Numerical studies are conducted to evaluate the bias and mean squared error of the estimators and the coverage probability of the confidence intervals.}, author = {Liu, Aiyi and Wu, Chengqing and Yu, Kai F.}, citeulike-article-id = {2534884}, citeulike-linkout-0 = {http://dx.doi.org/10.1080/10543400701697125}, doi = {10.1080/10543400701697125}, journal = {Journal of Biopharmaceutical Statistics}, keywords = {adaptive\_design, bias, confidence\_intervals, effect\_size, mean\_squared\_error, minimal\_sufficiency, pivot\_function, sample\_size\_reestimation}, number = {2}, pages = {211--226}, posted-at = {2008-03-14 21:47:12}, priority = {4}, publisher = {Taylor \& Francis}, title = {Point and Interval Estimation of Primary and Secondary Parameters in a Two-Stage Adaptive Clinical Trial}, url = {http://dx.doi.org/10.1080/10543400701697125}, volume = {18}, year = {2008} }

TY - JOUR ID - citeulike:2534884 L3 - citeulike-article-id:2534884 N2 - Investigated in this paper is the point estimation and confidence intervals of the treatment efficacy parameter and related secondary parameters in a two-stage adaptive trial. Based on the minimal sufficient statistics, several alternative estimators to the sample averages are proposed to reduce the bias and to improve the precision of estimation. Confidence intervals are constructed using Woodroofe's pivot method. Numerical studies are conducted to evaluate the bias and mean squared error of the estimators and the coverage probability of the confidence intervals. IS - 2 JF - Journal of Biopharmaceutical Statistics EP - 226 TI - Point and Interval Estimation of Primary and Secondary Parameters in a Two-Stage Adaptive Clinical Trial PB - Taylor & Francis VL - 18 SP - 211 KW - adaptive_design KW - bias KW - confidence_intervals KW - effect_size KW - mean_squared_error KW - minimal_sufficiency KW - pivot_function KW - sample_size_reestimation AU - Liu, Aiyi AU - Wu, Chengqing AU - Yu, Kai PY - 2008/// UR - http://dx.doi.org/10.1080/10543400701697125 ER -