Continuous Particle Separation Through Deterministic Lateral Displacement

by: Lotien R Huang, Edward C Cox, Robert H Austin, James C Sturm

Science, Vol. 304, No. 5673. (14 May 2004), pp. 987-990.

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Abstract

We report on a microfluidic particle-separation device that makes use of the asymmetric bifurcation of laminar flow around obstacles. A particle chooses its path deterministically on the basis of its size. All particles of a given size follow equivalent migration paths, leading to high resolution. The microspheres of 0.8, 0.9, and 1.0 micrometers that were used to characterize the device were sorted in 40seconds with a resolution of [~]10nanometers, which was better than the time and resolution of conventional flow techniques. Bacterial artificial chromosomes could be separated in 10 minutes with a resolution of [~]12%. 10.1126/science.1094567

@article{huang04, abstract = {We report on a microfluidic particle-separation device that makes use of the asymmetric bifurcation of laminar flow around obstacles. A particle chooses its path deterministically on the basis of its size. All particles of a given size follow equivalent migration paths, leading to high resolution. The microspheres of 0.8, 0.9, and 1.0 micrometers that were used to characterize the device were sorted in 40seconds with a resolution of [~]10nanometers, which was better than the time and resolution of conventional flow techniques. Bacterial artificial chromosomes could be separated in 10 minutes with a resolution of [~]12\%. 10.1126/science.1094567}, author = {Huang, Lotien R. and Cox, Edward C. and Austin, Robert H. and Sturm, James C. }, citeulike-article-id = {2030059}, doi = {10.1126/science.1094567}, journal = {Science}, keywords = {colloids, microfluidics}, month = {May}, number = {5673}, pages = {987--990}, posted-at = {2008-01-02 20:16:02}, priority = {5}, title = {Continuous Particle Separation Through Deterministic Lateral Displacement}, url = {http://dx.doi.org/10.1126/science.1094567}, volume = {304}, year = {2004} }

RIS record

TY - JOUR ID - huang04 TI - Continuous Particle Separation Through Deterministic Lateral Displacement JF - Science VL - 304 IS - 5673 SP - 987 EP - 990 N2 - We report on a microfluidic particle-separation device that makes use of the asymmetric bifurcation of laminar flow around obstacles. A particle chooses its path deterministically on the basis of its size. All particles of a given size follow equivalent migration paths, leading to high resolution. The microspheres of 0.8, 0.9, and 1.0 micrometers that were used to characterize the device were sorted in 40seconds with a resolution of [~]10nanometers, which was better than the time and resolution of conventional flow techniques. Bacterial artificial chromosomes could be separated in 10 minutes with a resolution of [~]12%. 10.1126/science.1094567 KW - colloids KW - microfluidics AU - Huang, Lotien AU - Cox, Edward AU - Austin, Robert AU - Sturm, James PY - 2004/05/14/ UR - http://dx.doi.org/10.1126/science.1094567 ER -

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